常见中草药提取物及主要成分对细胞色素P450 2C9抑制的研究进展

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摘要近年来中草药常与西药联合使用，用于疾病的预防和治疗。中草药成分复杂，可能影响药物代谢酶活性，存在引发中草药-药物相互作用（HDI）的潜在风险。目前HDI 尚未受到足够重视。I 相药物代谢酶细胞色素P450 2C9（CYP2C9）与超过15%的药物代谢相关，尤其是其底物包括几种治疗窗较窄的临床常用药物。关注中草药对该酶活性的影响，对HDI 的评估至关重要。本文综述了包括银杏、人参、丹参、生姜和大蒜等在内的常见中草药的提取物及其主要活性成分对CYP2C9 的抑制作用，旨在为临床中草药与西药的合理使用提供理论依据。

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	陈悦悦
	刘勇
	李冬冬
	黄豪
	曹耘铭
	丁倩
	李巍

关键词 ：细胞色素P450 2C9, 中草药, 药物代谢, 中药药物相互作用

Abstract：Chinese herbs and Western medicine are frequently applied in combination for disease treatment and prevention currently. The complicated components of Chinese Herbs may affect the activity of drug metabolism enzymes,and thus lead to herb-drug interaction (HDI). However, HDI has been neglected. Cytochrome P450 2C9 (CYP2C9), a phase I drug metabolism enzyme, is responsible for the metabolism of more than 15% drugs, including several narrow therapeutic window drugs. Evaluation of the CYP2C9 activity alteration is essential for HDI prediction. The current article reviewed the inhibitory effect on CYP2C9 of the common Chinese herbal extracts and major components, such as Ginkgo Biloba, Ginseng, Danshen, Ginger and Garlic. The aim is to provide theoretical basis for rational use of Chinese herbs and Western medicine in clinic.

Key words： Cytochrome P450 2C9 Chinese herbs Drug metabolism Herb-drug interaction

基金资助:国家重点研发计划课题（2017YFC1702006）；江苏省扬州市科技计划项目（市级计划——社会发展项目）（YZ2020084）；扬州大学大学生科创基金项目（X20190747、X20190746、X20200754）

通讯作者: 李巍（1982-），女，辽宁开原人，博士，讲师，研究方向：药物代谢

作者简介: 陈悦悦（1994-），女，扬州大学医学院2019 级中药学专业在读硕士研究生，研究方向：药物代谢

引用本文:

陈悦悦；刘勇；李冬冬；黄豪；曹耘铭；丁倩；李巍. 常见中草药提取物及主要成分对细胞色素P450 2C9抑制的研究进展[J]. 中国当代医药, 2021, 28(16): 25-31.
CHEN Yue-yue；LIU Yong；LI Dong-dong；HUANG Hao；CAO Yun-ming；DING Qian；LI Wei. Research progress in the investigation of inhibitory effect of common Chinese herbal extracts and major components on Cytochrome P450 2C9. 中国当代医药, 2021, 28(16): 25-31.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I16/25

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