Effect of Ticagrelor combined with percutaneous coronary intervention in the treatment of patients with acute ST segment elevation myocardial infarction
ZHANG Li-wei
Department of Emergency, Lianshan District, Huludao Central Hospital
Abstract:Objective To observe the clinical efficacy and safety of Ticagrelor combined with percutaneous coronary intervention (PCI) in patients with acute ST segment elevation myocardial infarction. Methods A total of 100 patients with acute ST segment elevation myocardial infarction who were treated in Huludao Central Hospital from January to October 2019 were selected and divided into the experimental group and the control group according to the random number table method. The control group was treated with Clopidogrel combined with PCI, and the experimental group was treated with Ticagrelor combined with PCI. The clinical efficacy and safety of treatment were compared between the two groups. Results After treatment, the platelet count and platelet aggregation rate of the experimental group were lower than those of the control group, the differences were statistically significant (P<0.05); the values of endothelial cell specific molecule-1 (ESM-1), interleukin-6 (IL-6) and high sensitivity C-reactive protein (hs-CRP) of the experimental group were lower than those of the control group, the differences were statistically significant (P<0.05). After treatment, the values of creatine kinse isoenzymec (CK-MB) and cardiac troponin I (cTn I) in the experimental group were lower than those in the control group, and the differences were statistically significant (P<0.05); the LVEF score in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05); the adverse cardiovascular events in the experimental group during treatment was lower than the control group,the difference was statistically significant (P<0.05). Conclusion Ticagrelor combined with PCI for patients with acute ST segment elevation myocardial infarction has significant effect and high safety, which can be widely used.
张立伟. 替格瑞洛联合经皮冠状动脉介入术在治疗急性ST段抬高型心肌梗死患者中的效果[J]. 中国当代医药, 2021, 28(16): 17-20.
ZHANG Li-wei. Effect of Ticagrelor combined with percutaneous coronary intervention in the treatment of patients with acute ST segment elevation myocardial infarction. 中国当代医药, 2021, 28(16): 17-20.