Abstract：Objective To investigate the effect of low tidal volume combined with positive end-expiratory pressure on respiratory function of single lung ventilation.Methods From May 2018 to April 2019，80 patients undergoing general anesthesia thoracotomy under double-lumen endotracheal intubation admitted to our hospital were selected as research objects，and divided into observation group（40 cases）and control group（40 cases）according to the random number table method.For respiratory parameters of one lung ventilation，the control group was given conventional mode，while the observation group was given low tidal volume combined with positive end-expiratory pressure.The anesthesia recovery conditions of the two groups of patients（time of opening eyes，removing tracheal catheter and indwelling in recovery room），Ramsay score in recovery period 30min and 2 h after anesthesia stop，changes of pulmonary function index（percentage of forced expiratory volume in the first second to the expected value [FEV1%]and forced vital capacity/whole vital capacity in the first second [FEV1/FVC]）after operation 24h，and the occurrence of adverse reactions（hypoxemia，respiratory depression and hypercapnia）of the two groups patients were compared.Results The observation group had shorter time to open eyes，pull out endotracheal tube and indwelling in resuscitation room than the control group（P＜0.05）.The Ramsay score of the observation group were higher than those of the control group 30min and 2 h after anesthesia was stopped（P＜0.05）.At 24h after operation，FEV1% and FEV1/FVC in the observation group were higher than those in the control group（P＜0.05）.The total incidence of adverse reactions in the observation group was lower than that in the control group，and the difference was statistically significant（P＜0.05）.Conclusion For patients with one lung ventilation，low tidal volume and low positive end-expiratory pressure ventilation can effectively maintain the lung function of patients，promote anesthesia recovery of patients，and reduce the occurrence of respiratory-related complications.
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