Abstract：Objective To explore the effect of demethylation agents combined with CAG regimen in the treatment of acute myeloid leukemia in the elderly.Methods A total of 62 cases of elderly patients admitted for acute myeloid leukemia in our hospital from June 2013 to June 2018 were retrospectively analyzed, according to the different treatment methods, they were divided into the control group (34 cases) and the observation group (28 cases).The patients in the control group were treated with CAG regimen, while those in the observation group were treated with demethylation drugs plus CAG regimen (Aclacinomycin+Cytarabine+Granulocyte Colony Stimulating Factor).The clinical efficacy and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 75.00%, which was significantly higher than 55.88% of the control group, the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of pulmonary infection, heart failure, nausea and vomiting,liver function damage, thrombocytopenia and granulocytopenia between the two groups (P＞0.05).Conclusion The clinical effect of demethylation drug plus CAG regimen in the treatment of elderly patients with acute myeloid leukemia is good, and it is safe and reliable.It does not increase the probability of complications.It is worthy of clinical promotion and application.
李卫华；郭子文；何慧清；牛晓敏；黎伟超. 去甲基化药物联合CAG方案治疗老年急性髓系白血病的效果[J]. 中国当代医药, 2019, 26(12): 61-63.
LI Wei-hua；GUO Zi-wen；HE Hui-qing；NIU Xiao-min；LI Wei-chao. Effect of demethylated drugs combined with CAG regimen in the treatment of acute myeloid leukemia in the elderly. 中国当代医药, 2019, 26(12): 61-63.
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