颈淋巴结核对罗库溴铵肌松效应的影响

摘要
图/表
参考文献(18)
相关文章 (0)

全文: PDF (0 KB) HTML (35 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨颈淋巴结核对罗库溴铵按体表面积给药肌松效应的影响。方法选取2017年5～10月于我院行全麻下颈部肿物切除手术40例患者作为研究对象，按照疾病类型将其分为结核病组（T组）与非结核病组（NT组），每组各20例。全麻诱导时按体表面积计算给予2倍ED95罗库溴铵，待拇内收肌四个成串刺激（TOF）第4个肌颤搐与第1个肌颤搐的比值（T4/T1，TOFr）降至0%时行气管插管。记录两组患者的气管插管条件、起效时间、临床作用时间、恢复指数及药理作用时间。结果两组患者的气管插管条件比较，差异无统计学意义（P＞0.05）。两组患者的起效时间、恢复指数及药理作用时间比较，差异无统计学意义（P＞0.05）；T组患者的罗库溴铵临床作用时间为（24.0±4.6）min，明显短于 NT 组的（28.0±3.6）min，差异有统计学意义（P＜0.05）。结论颈淋巴结核患者罗库溴铵按体表面积给药的临床作用时间较非结核患者短，围术期追加用药的间隔时间宜适当缩短。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	韩亚坤
	刘民强
	余德慧
	胡菽君

关键词 ：颈淋巴结核, 罗库溴铵, 体表面积, 药效学

Abstract：Objective To investigate the influence of cervical lymphatic tuberculosis on the muscle relaxation effect of Rocuronium Bromide when administrated by body surface area.Methods Forty patients who underwent general anesthesia for neck mass resection in our hospital from May to October 2017 were selected as study objects and they were divided into tuberculosis group(group T)and non-tuberculosis group(group NT)according to the disease type,20 cases in each group.In the induction of general anesthesia,according to the body surface area,2 times of ED95 Rocuronium Bromide was administered.The tracheal intubation was performed when the ratio of the fourth muscle twitch to the first muscle twitch(T4/T1,TOFr)of the train-of-four(TOF)stimulation of the abductor pollicis muscle was reduced to 0%.The tracheal intubation conditions,onset time,clinical duration,recovery index and pharmacological time were recorded between the two groups.Results There were no significant differences in tracheal intubation conditions between the two groups(P＞0.05).There were no significant differences in onset time,recovery index and pharmacological time between the two groups (P＞0.05).The clinical duration of Rocuronium Bromide in group T was (24.0±4.6)min,which was significantly shorter than that in group NT of(28.0±3.6)min,and the difference was statistically significant(P＜0.05).Conclusion The clinical action duration of administration of Rocuronium Bromide in patients with cervical lymphatic tuberculosis by body surface area is shorter than that of non-tuberculosis patients,and the interval between additional medications during perioperative period should be appropriately shortened.

Key words： Cervical lymphatic tuberculosis Rocuronium Bromide Body surface area Pharmacodynamics

引用本文:

韩亚坤; 刘民强; 余德慧 ; 胡菽君. 颈淋巴结核对罗库溴铵肌松效应的影响[J]. 中国当代医药, 2019, 26(8): 144-146.
HAN Ya-kunl; LIU Min-qiang; YU De-hui; HU Shu-jun. Influence of cervical lymphatic tuberculosis on muscle relaxation effect of Rocuronium Bromide. 中国当代医药, 2019, 26(8): 144-146.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2019/V26/I8/144

[1]	Gao J，Wang J，Gao N，et al.Prediction of cytochrome P450-mediated drug clearance in humans based on the measured activities of selected CYPs[J].Biosci Rep，2017，37（6）：BSR 20171161.
[2]	Hassan STSM，Berchov，et al.Antimycobacterial，enzyme inhibition，and molecular interaction studies of psoromic acid in Mycobacterium tuberculosis：efficacy and safety investigations[J].J Clin Med，2018，7（8）：E226.
[3]	Benefield RJ，Slechta ES，Gast CM，et al.Comparison of the drug-drug interaction potential of daptomycin in combination with rifampin in healthy adult volunteers[J].Antimicrob Agents Chemother，2018，62（12）：e01525.
[4]	Srinivas NR.Pharmacokinetic interaction of rifampicin with oral versus intravenous anticancer drugs：challenges，dilemmas and paradoxical effects due to multiple mechanisms[J].Drugs R D，2016，16（2）：141-148.
[5]	Dalton AJ，Millar F.Neuromuscular monitoring and the AAGBI 2016 monitoring guidelines[J].Anaesthesia，2016，71（8）：981-982.
[6]	Koo CH，Chung SH，Kim BG，et al.Comparison between the effects of deep and moderate neuromuscular blockade during transurethral resection of bladder tumor on endoscopic surgical condition and recovery profile：a prospective，randomized，and controlled trial[J].World J Urol，2018[Epub ahead of print].
[7]	王冬梅，徐世元，张新建，等.按体表面积给药测定罗库溴铵 ED95剂量[J].实用医学杂志，2010，26（7）：1152-1154.
[8]	Fuchs-Buder T，Schmartz D.Residual neuromuscular blockade[J].Anaesthesist，2017，66（6）：465-476.
[9]	Thomsen JLD，Mathiesen O，Hagi-Pedersen D，et al.Improving neuromuscular monitoring and reducing residual neuromuscular blockade with E-learning：protocol for the multicenter interrupted time series INVERT study[J].JMIR Res Protoc，2017，6（10）：e192.
[10]	Muramatsu T，Isono S，Ishikawa T，et al.Differences of recovery from rocuronium-induced deep paralysis in response to small doses of Sugammadex between elderly and nonelderly patients[J].Anesthesiology，2018，129（5）：901-911.
[11]	Cokol M，Kuru N，Bicak E，et al.Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis[J].Sci Adv，2017，3（10）：e1701881.
[12]	Fortier LP，McKeen D，Turner K，et al.The RECITE study：a Canadian prospective，multicenter study of the incidence and severity of residual neuromuscular blockade[J].Anesth Analg，2015，121（2）：366-372.
[14]	刘民强，陈爱华，康京华，等.结核病患者维库溴铵药效学参数的测定[J].南昌大学学报（医学版），2015，55（2）：40-43.
[16]	周翠云，邢祖民，磨凯，等.比较罗库溴铵按体表面积与实际体重间断静注给药的药效学[J].实用医学杂志，2014，30（6）：959-962.
[13]	Murphy GS，Szokol JW，Avram MJ，et al.Residual neuromuscular block in the elderly：incidence and clinical implications[J].Anesthesiology，2015，123（6）：1322-1336.
[15]	Hayao K，Tamaki H，Nakagawa K，et al.Effects of streptomycin administration on increases in skeletal muscle fiber permeability and size following eccentric muscle contractions[J].Anat Rec（Hoboken），2018，301（6）：1096-1102.
[17]	Van Gasse AL，Elst J，Bridts CH，et al.Rocuronium hypersensitivity：does off-target occupation of the MRGPRX2 receptor play a role？[J].J Allergy Clin Immunol Pract，2018，16（2）：366-369.
[18]	Yellott E，Badeaux J，Martin J，et al.Effectiveness of sugammadex versus neostigmine on restoration of neuromuscular function in surgical patients with myasthenia gravis undergoing rocuronium-induced neuromuscular blockade：a systematic review protocol[J].JBI Database System Rev Implement Rep，2018，16（10）：1922-1928.