Effect of PM2.5 exPosure for Peritoneal macroPhages of tumor-bearing mice with lung cancer treated by bruceolic oil emulsion
YANG Biao1 LI Xin-ming2 YAN Si-yuan2 CHEN Dong-mei2 NIU Jia-yu2 XIAO Chun-ling2▲
1.Liaoning University of Traditiona1 Chinese Medicine，Shenyang 110032，China；
2.Key Lab of Environmenta1 Po11ution and Microeco1ogy，Shenyang Medica1 Co11ege，Shenyang 110034，China
Abstract：Objective To exp1ore active regu1ating effect of PM2.5 exposure for peritonea1 macrophages of tumor-bearing mice with 1ung cancer treated by bruceo1ic oi1 emu1sion. Methods 32 mouse mode1s in tumor-bearing A549 ce11 in 1ung cancer were random1y divided into 4 groups:treatment group 1 (bruceo1ic oi1 emu1sion treatment group) and contro1 group 1，treatment group 2 (PM2.5 exposure combined with bruceo1ic oi1 emu1sion treatment group) and contro1 group 2. Each group had eight mice.Peritonea1 macrophages from these mice were co11ected and 520 nm absorbance degree va1-ue was detected. Results phagocytic abi1ity of peritonea1 macrophage indicated that treatment group 1 was higher than that of contro1 group 1，and there was a statistica1 difference (P＜0.05).The phagocytic abi1ity in the treatment group 2 was 1ower than that of contro1 group 2，and the phagocytic abi1ity in the treatment group 1 was higher than that of treatment group 2，and there was a statistica1 difference (P＜0.01). Conclusion PM2.5 exposure has inhibiting effect for activity of peritonea1 macrophages in tumor-bearing mice with 1ung cancer treated by bruceo1ic oi1 emu1sion.
杨彪;李新呜;严思远;陈冬梅;牛佳钰;肖纯凌. PM2.5暴露对鸦胆子油乳治疗荷瘤肺癌小鼠腹腔巨噬细胞的作用[J]. 中国当代医药, 2016, 23(6): 15-17转21.
YANG Biao;LI Xin-ming;YAN Si-yuan;CHEN Dong-mei;NIU Jia-yu;XIAO Chun-ling. Effect of PM2.5 exPosure for Peritoneal macroPhages of tumor-bearing mice with lung cancer treated by bruceolic oil emulsion. 中国当代医药, 2016, 23(6): 15-17转21.
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