ObjectiveBy observing the clinical effect of continuous renal replacement therapy in patients with severe sepsis to analysis the feasibility of continuous renal replacement for severe sepsis.Methods13 patients with severe sepsis who received：continuous renal replacement therapy in our hospital from March 2015 to March 2016 were selected as observation group,13 patients with severe sepsis who had undergone continuous renal replacement therapy without conventional therapy were selected as the control group,the clinical data of the two groups were recorded before and after treatment,including lactic acid,procalcitonin,oxygenation index,urine output and so on,to compare the treatment and mortality of two groups.ResultsThere was a significant difference between the two groups in the severity of disease(APCHEⅡ score)and organ failure(SOFA score),the difference was not statistically significant(P>0.05)；Comparison of the two groups of patients in the short term lactate,procalcitonin decreased,increased oxygenation index and urine recovery,the observation group was significantly better,their difference was statistically significant(P<0.05)；The mortality rate in the acute phase (7 days)was 7.69%,and significantly decreased compared with the control group (38.46%),the difference was statistically significant(P<0.05).ConclusionContinuous renal replacement therapy can improve the success rate of acute sepsis in patients with severe sepsis,has a certain feasibility,can be applied in clinical practice.