适形调强放疗+口服卡培他滨对Ⅱ、Ⅲ期直肠癌术后患者的治疗效果

摘要
图/表
参考文献
相关文章 (0)

全文: PDF (377 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的研究适形调强放疗+口服卡培他滨对Ⅱ、Ⅲ期直肠癌术后患者的治疗效果。方法选取2013年2月~2015年3月我院诊治的86例直肠癌Ⅱ、Ⅲ期患者,随机分成研究组与对照组,各43例。全部患者均常规实施手术治疗,研究组在术后对患者实施适形调强放疗与卡培他滨联合治疗,对照组术后单纯应用适形调强放疗治疗,评价分析患者的治疗效果。结果研究组的总有效率（83.72%）明显高于对照组（62.79%）,差异有统计学意义（P<0.01）;研究组的术后2年无病生存率、总生存率明显高于对照组,局部复发率明显低于对照组,差异有统计学意义（P<0.05）;研究组的不良反应发生率（44.19%）也明显低于对照组（65.12%）,差异有统计学意义（P<0.01）。结论 Ⅱ、Ⅲ期直肠癌患者在手术治疗后给予适形调强放疗与卡培他滨口服联合治疗,具有显著的临床效果。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李穗华
	罗金现

关键词 ：直肠癌, Ⅱ、Ⅲ期, 适形调强放疗, 卡培他滨

Abstract：Objective To study and analyze the treatment effects of conformal intensity-modulated radiation therapy and oral Capecitabine for postoperative care of patients with stage Ⅱ and Ⅲ rectal cancer.Methods 86 cases of patients with stage Ⅱ and Ⅲ of rectal cancer and who received the treatment in our hospital from February 2013 to March 2015 were selected,and the patients were randomly divided into study group and control group,with 43 cases in each group.All the selected patients were implemented the routine surgery treatment,and the study group were implemented conformal intensity-modulated radiotherapy combined with Capecitabine,while the control group were only treated with conformal intensity-modulated radiation therapy.Then,the clinical effect of two groups was evaluated and analyzed.Results The treatment efficiency in the study group was 83.72%,which was significantly higher than that in the control group of 62.79%,with statistical significance (P<0.01);the disease-free survival rate, overall survival rate and local recurrence rate after the operation for 2 years in the study group were significantly better than those in the control group, with statistical significance (P<0.05).And the incidence of adverse reactions in the study group was 44.19%,which was significantly lower than that in the control group of 65.12%, with statistical significance (P<0.01).Conclusion The treatment effects of conformal intensity-modulated radiotherapy combined with Capecitabine oral administration for patients with stage Ⅱ and Ⅲ rectal cancer,which it has significant clinical effect.

Key words： Rectal cancer Stage Ⅱ and Ⅲ Conformal intensity-modulated radiotherapy Capecitabine

收稿日期: 2017-07-07

PACS:

R735.37

作者简介: 李穗华（1979-）,女,广东广州人,本科,副主任药师;研究方向：药学

引用本文:

李穗华, 罗金现. 适形调强放疗+口服卡培他滨对Ⅱ、Ⅲ期直肠癌术后患者的治疗效果[J]. 中国当代医药, 2017, 24(24): 39-41.
LI Sui-hua, LUO Jin-xian. Treatment effect of conformal intensity-modulated radiation therapy and oral Capecitabine for patients with stage Ⅱ and Ⅲ rectal cancer in postoperative nursing. 中国当代医药, 2017, 24(24): 39-41.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I24/39

[1]	朱卫国,韩济华,李涛,等.三维适形放疗并FOLFOX6方案治疗直肠癌术后局部复发前瞻性研究[J].实用医学杂志,2010,26（13）：2343-2346.
[2]	李显蓉,杨庆强,徐林霞,等.腹腔镜手术在老年直肠癌患者中的应用及围手术期护理[J].实用医学杂志,2012,28（1）：150-153.
[3]	肖林,祝喻甲,邱波,等.局部进展期直肠癌术前3DCRT或VMAT同期化疗后肠壁残余癌细胞分布比较[J].中华放射肿瘤学杂志,2016,25（7）：708-712.
[4]	弋振营,李宁,高岭,等.调强适形放射治疗联合替吉奥化学治疗直肠癌术后放疗后局部复发性直肠癌的临床疗效及安全性分析[J].转化医学电子杂志,2015,28（6）：26-27.
[5]	叶卫华,王贵英,韩若凌,等.经直肠超声在评价直肠癌术前新辅助放化疗疗效中的价值[J].中国超声医学杂志,2013, 29（4）：351-354.
[6]	莫凯岚,陈斯泽,钟毓平,等.调强适形放疗同步化疗联合内生场热疗治疗复发和局部晚期直肠癌的近期疗效[J].广东医学,2015,21（16）：2467-2470.
[7]	陈世梅,李莉.XELOX方案同期化疗联合调强适形放疗治疗复发和局部晚期直肠癌的护理[J].肿瘤预防与治疗,2011,24（4）：176-179.
[8]	胡克,庞廷田,杨波,等.直肠癌术前放疗中三维适形放疗与调强适形放疗的剂量学比较分析[J].中华放射医学与防护杂志,2010,30（3）：310-313.
[9]	丁叔波,胡望远,黎萍,等.局部晚期直肠癌新辅助治疗同期加量调强与三维适形放疗随机对照研究[J].中华放射医学与防护杂志,2016,36（4）：283-287.
[10]	廖盛日,范智慧,严昆,等.经直肠超声对放化疗后直肠癌浸润深度判断价值探讨[J].中国超声医学杂志,2012, 28（3）：259-262.
[11]	刘晓平,周小青,邓伟,等.直肠癌白细胞介素-6的表达与临床病理因素的相关性研究[J].中国现代医学杂志,2016,26（6）：23-26.
[12]	肖若冰,肖雅莉,谢海辉,等.直肠癌术前卡培他滨联合两种周期放疗方案疗效研究[J].中国现代医学杂志,2014, 24（4）：62-65.
[13]	依力哈木,马合木提江,亚力坤,等.放射治疗对直肠癌细胞凋亡及相关调控蛋白的影响[J].中国现代医学杂志,2010,20（20）：3118-3121.
[14]	孙彩萍,王建芳,叶万立,等.直肠癌术后调强放疗和适形放疗靶区剂量学研究及危及器官毒性观察[J].中国现代医学杂志,2014,24（1）：54-57.
[15]	孔刚,刘虹,龚志军,等.贝伐单抗联合XELOX方案诱导化疗对局部晚期直肠癌有效性及安全性的临床观察[J].中国现代医学杂志,2015,25（3）：86-90.