Com parison of clinical effect of intensity modulated radiotherapy and conventional radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma
YAN Shao-cong1 YING Xue-ming1▲ XIONG Jian-ping2 ZHAO Jian-hua1
1.Departmentof Oncology,Jingdezhen First People′s Hospital,Jiangxi Province,Jingdezhen 333000,China;
2.Department of Oncology,the First Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330006,China
Abstract：Objective To compare the clinical effect of intensitymodulated radiotherapy (IMRT)and conventional radiotherapy(CRT)in the treatment of locally advanced nasopharyngeal carcinoma.Methods Totally 85patientswith locally advanced nasopharyngeal carcinoma admitted into the First Affiliated Hospital of Nanchang University from January 2010 to December 2013were selected as research subjects.They were divided into the CRT group(n=39)and the IMRT group (n=46)according to different treatmentmethods.The CRT group was treated with CRT,and the IMRT group was treated with IMRT.The clinical remission rate,5-year survival rate without local progression,5-year survival rate without distantmigration,overall survival rate and the incidence of early and late adverse reactions were compared between the two groups.Results The clinical remission rate of the IMRT group was 69.5%,which was higher than that of the CRT group accounting for 25.6%,the difference was statistically significant(P＜0.05).The degree of early radiation loss of drymouth and acute skin reactions in the IMRT group were lighter than those of the CRT group,the differenceswere statistically significant(P＜0.05).The degree of late radiation loss of drymouth,skin fibrosis,and difficulty in openingmouth in the IMRT group were lighter than those of the CRT group,and the differenceswere statistically significant(P＜0.05).The 5-year survival ratewithout local progression in the IMRT group was 21.7%,which was higher than that of the CRT group accounting for 13.7%,the differencewas statistically significant(P＜0.05).Conclusion Applying IMRT to patientswith locally advanced nasopharyngeal carcinoma can significantly increase the clinical remission rate,alleviate patients′adverse reactions and prolong the survival time of patientswho had no local progression.
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