Abstract：Objective To compare the clinical effects between nasal continuous positive airway pressure(NCPAP)and nasal bi-level positive airway pressure(NBiPAP)ventilation in treating respiratory distress syndrome（RDS）in newborns.Methods Eighty newborns with RDS who were born in our hospital from July 2013 to March 2015 were selected as study subjects and divided into observation group and control group by random number table method,40 cases in each group.After tracheal intubation weaning,patients in the observation group were treated by NBiPAP ventilation,while patients in the control group were treated by NCPAP ventilation.The success rate of treatment was compared between two groups,and the partial pressure of blood oxygen(PaO2),pH value and complications were recorded.The changes of fasting blood glucose,neutrophils and platelet count were compared between two groups.Results The success rate of treatment in the observation group was 85.0%,significantly higher than 65.0%in the control group(P<0.05).There was no significant difference in the incidence of complications between two groups(17.5%vs 10.0%)(P>0.05);after treatment,pH and PaO2in the observation group was higher than that in the control group(P<0.05).The hospitalization time in the observation group was(13.74±1.08)d,shorter than(16.07±1.29)d in the control group(P<0.05).There were no significant changes of blood glucose,neutrophils and platelet count in observation group before and after treatment(P> 0.05),while which in the control group was significantly lower than that in observation group after treatment(P<0.05). Conclusion The effect of NBiPAP ventilation in the treatment of RSD in newborns is better,and the safety is higher than NCPAP ventilation.It is worth to be popularized in clinical application.
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