α-环糊精/聚乙二醇准聚轮烷触变水凝胶的制备及其流变学性质研究

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摘要目的研究不同处方因素对α-环糊精/聚乙二醇（α-CD/PEG）准聚轮烷水凝胶流变学性质的影响。　方法以α-环糊精（α-CD）为主体分子，聚乙二醇（PEG）为客体分子轴，采用水浴超声法制备了具有超分子结构的α-CD/PEG准聚轮烷水凝胶，对不同处方因素的影响进行考察。结果提高PEG的浓度和分子量均能增加α-CD/PEG准聚轮烷水凝胶的黏度；加入无机盐，可使成胶时间延长，黏度降低。PEG分子量＞8000时，形成的准聚轮烷水凝胶具有一定的触变性。结论PEG分子量＞8000时形成的α-CD/PEG准聚轮烷水凝胶，有望成为一种良好的缓释给药载体材料。

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	刻松华
	姜英子
	李琳
	全东琴

关键词 ：准聚轮烷水凝胶, 环糊精, 聚乙二醇, 触变性

Abstract：Objective To study the inf1uence of different prescription factors on rheo1ogica1 properties of α-cyc1odextrin/po1yethy1ene g1yco1（α-CD/PEG）pseudo-po1yrotaxanes thixotropic hydroge1.Methods α-cyc1odextrin（α-CD）was se1ected as host mo1ecu1e，po1yethy1ene g1yco1（PEG）was chosen as guest mo1ecu1e axis，and α-CD/PEG pseudo-po1yrotaxanes thixotropic hydroge1 in supramo1ecu1ar structure was prepared by water bath u1trasound.Inf1uence on different prescription factors was observed.Results Viscosity of α-CD/PEG pseudo-po1yrotaxanes thixotropic hydroge1 cou1d be intensified by increase of PEG concentration and mo1ecu1ar weight.Once inorganic sa1t was added，the ge11ing time was pro1onged and viscosity was reduced.If mo1ecu1ar weight of PEG was more than 8000，certain thixotropy existed in the formed pseudo-po1yrotaxanes thixotropic hydroge1.Conclusion When mo1ecu1ar weight of PEG is more than 8000，the formed α-CD/PEG pseudo-po1yrotaxanes thixotropic hydroge1 is expected to be favorab1e materia1 to be a sustained re-1ease carrier.

Key words： Pseudo-po1yrotaxanes thixotropic hydroge1 Cyc1odextrin Po1yethy1ene g1yco1 Thixotropy

作者简介: 刘松华（1990-），女，硕士，研究方向：药物新剂型与制剂新技术

引用本文:

刻松华;姜英子;李琳;全东琴. α-环糊精/聚乙二醇准聚轮烷触变水凝胶的制备及其流变学性质研究[J]. 中国当代医药, 2016, 23(14): 7-09.
LIU Song-hua;JIANG Ying-zi;LI Lin;QUAN Dong-qin. PreParation of α-cyclodextrin/Polyethylene glycol Pseudo-Polyrotaxanes thixotroPic hydrogel and study of its rheological ProPerties. 中国当代医药, 2016, 23(14): 7-09.

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