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| Clinical application of music therapy in treatment of Alzheimer′s disease |
| LI Yan-ling1 WANG Xiu2 SHAN Shu-zhen1▲ WANG Wei3 |
1.Department of Neurology, Xinhua Hospital Affiliated to Dalian University
2. Graduate School of Dalian University
3. Department of Rehabilitation,Zhongshan Hospital Affiliated to Dalian University |
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Abstract Objective To observe the effect of music therapy on behavioral and psychological symptoms of patients with Alzheimer's disease (AD). Methods Eighty patients with AD treated in Xinhua Hospital Affiliated to Dalian University from April 2017 to April 2020 were selected as research subjects, and were divided into the treatment group (n=40)and the control group (n=40) according to the lot drawing method. Music therapy plus memantine therapy was given to the treatment group, and memantine therapy was given to the control group, with the treatment course of 16 weeks. The decreased score of neuropsychiatric inventory (NPI) after the treatment and the mini-mental state examination (MMSE)score before and after the treatment in the two groups were compared. Results In the comparison of decreased scores of NPI after the treatment in the two groups, the decreased scores of delusion, hallucination, agitation/aggression, depression/dysphoria, anxiety, and apathy/indifference in the treatment group were higher than those in the control group, with statistical differences (P<0.05); there were no statistically significant differences in the decreased scores of elation/euphoria, disinhibition, irritability/lability, motor disturbance, nightime behaviors or appetite/eating between the two groups (P＞0.05). The decreased score of MMSE (the difference score between before and after the treatment) in the treatment group was (0.931±0.101) points, higher than that in the control group of (0.272±0.081), with statistical difference(P<0.05). Conclusion Music therapy can improve behavioral and psychological symptoms of patients with AD especially in agitation/aggression, apathy/indifference, depression/dysphoria, delusion, hallucination, and anxiety, and can also improve cognitive function.
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