桃仁红花煎联合伊伐布雷定治疗血络瘀阻型持续性房颤的临床效果

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Abstract Objective To observe and explore the clinical effect of Taoren Honghua Decoction combined with Ivabradine in the treatment of persistent atrial fibrillation of blood collateral stasis type. Methods A total of 120 patients with persistent atrial fibrillation of blood collateral stasis type admitted to the Department of Cardiology of Hubei Integrated Traditional and Western Medicine Hospital from April to August 2020 were selected as the research subjects. According to the different treatment methods,the patients were divided into treatment group (65 cases) and control group (55 cases).Patients in both groups were given basic symptomatic treatment. Patients in the control group were treated with Ivabradine alone, and patients in the treatment group were treated with Taoren Honghua Decoction combined with Ivabradine.The clinical efficacy of the two groups was compared. The indexes of dynamic electrocardiograph ventricular rate (resting ventricular rate, 24 h mean ventricular rate, 24 h fastest ventricular rate, 24 h slowest ventricular rate), the 6 min walking distance, cardiac function indexes (left atrial diameter [LAD1], left ventricular ejection fraction[LVEF]), serological indexes (troponin [cTn], high-sensitive C-reactive protein [hs-CRP], N-terminal B-type natriuretic peptide precursor [NT-proBNP], aldosterone [Ald]) before and after treatment were compared between the two groups.The results of safety monitoring were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 92.31%, which was higher than that of the control group (78.18%), the difference was statistically significant (P<0.05). After treatment, the resting ventricular rate, 24 h mean ventricular rate, 24 h fastest ventricular rate and 24 h slowest ventricular rate in the two groups were lower than those before treatment, and the 6 min walking distance was longer than that before treatment, with statistically significant differences (P<0.05). After treatment, the resting ventricular rate, 24 h mean ventricular rate, 24 h fastest ventricular rate and 24 h slowest ventricular rate in the treatment group were lower than those in the control group, and the 6 min walking distance was longer than that in the control group, with statistically significant differences (P<0.05). After treatment, LAD1 in the treatment group was less than that before treatment, and LVEF was greater than that before treatment, with statistically significant differences (P<0.05). After treatment, LAD1 in the treatment group was lower than that in the control group, and LVEF in the treatment group was greater than that in the control group, with statistically significant differences (P<0.05). After treatment, the levels of hs-CRP, NT-proBNP, Ald and cTn in the two groups were all lower than those before treatment, with statistically significant differences (P<0.05). The levels of hs-CRP, NT-proBNP, Ald and cTn in the treatment group were all lower than those in the control group after treatment, with statistically significant differences (P<0.05). There was no statistical significance in the incidence of adverse drug reaction between the two groups (P>0.05).Conclusion The clinical effect of Taoren Honghua Decoction combined with Ivabradine in the treatment of patients with persistent atrial fibrillation of blood collateral stasis type is better than that of Ivabradine alone, which is worthy of clinical application.

Key words： Taoren Honghua Decoction Ivabradine Persistent atrial fibrillation Integrated traditional Chinese and Western medicine

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	TAN Ju-lang
	HU Xiao-jun
	ZHANG Zhen
	ZHAO Dai-xin

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TAN Ju-lang,HU Xiao-jun,ZHANG Zhen, et al. Clinical effect of Taoren Honghua Decoction combined with Ivabradine in the treatment of persistent atrial fibrillation of blood collateral stasis type[J]. 中国当代医药, 2021, 28(16): 178-183.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I16/178

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