不同激素量联合环磷酰胺及雷公藤治疗中老年肾病综合征的效果

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Abstract Objective To explore the clinical effect of different dosage hormone combined with Cyclophosphamide and Tripterygium Wilfordii in the treatment of nephrotic syndrome in middle and old aged patients.Methods 100 middle and old aged patients with nephrotic syndrome in our hospital from March 2014 to February 2016 were selected.Patientsweredividedinto Ⅰ,Ⅱ,Ⅲ and Ⅳgroups,andeach group was 25 cases.On the basis of Cyclophosphamide and Tripterygium Wilfordii,patients in different groups were treated with different doses of prednisone acetate.The dosage and medication of prednisone acetate for four groups of patients were as follows： group Ⅰ[0.4 mg/(kg·d)];group Ⅱ[0.6 mg/(kg·d)];group Ⅲ[0.8 mg/(kg·d)];group Ⅳ[1.0 mg/(kg·d)],and were taken in every morning.3 months later,the treatment effect among four groups were compared.Results After 3 months of continuous treatment,the effective rate of clinical treatment in groupⅣwas 100%,significantly higher than 92%in the other three groups,and in the improvement of urine protein content,plasma albumin level,blood creatinine and other indicators,it was also significantly better than the other three groups,and the difference was significant(P＜0.05).Conclusion Cyclophosphamide combined with Tripterygium Wilfordii and prednisone acetate in the treatment of nephrotic syndrome in middle-aged and elderly patients can achieve better results,especially when the dose hormone drug prednisone acetate is 1.0 mg/(kg·d),the treatment is best.Therefore,it has good clinical application and promotion value.

Key words： Nephrotic syndrome Tripterygium Wilfordii Cyclophosphamide

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	HU Chun-an
	GAN Niu-qin

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HU Chun-an,GAN Niu-qin. Effect of different dosage hormone combined with Cyclophosphamide and Tripterygium Wilfordii in the treatment of nephrotic syndrome in middle and old aged patients[J]. 中国当代医药, 2017, 24(28): 144-146.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I28/144

[1]	刘金平.中老年原发性肾病综合征应用雷公藤多苷辅助治疗效果观察[J].当代医学，2016，22（18）：135-136.
[2]	李小红，李清初，李康慧，等.中老年原发性肾病综合征应用雷公藤多苷辅助治疗效果观察[J].中国临床保健杂志，2015（5）：514-516.
[3]	韦东艳，廖家贤.环磷酰胺冲击联合激素治疗难治性肾病综合征的疗效观察[J].中国医药指南，2016， 14（24）：129-130.
[4]	谢光杰，易富敢.足量激素联合环磷酰胺治疗难治性肾病综合征临床分析[J].淮海医药，2017，35（2）：220-221.
[5]	周振中.小剂量强的松联合雷公藤多苷治疗老年原发性肾病综合征的临床疗效观察[J].现代诊断与治疗，2015，26（21）：4860-4861.
[6]	阿迪力江·喀日，扎依旦·艾力，罗燕飞，等.环磷酰胺联合强的松治疗儿童肾病综合征型紫癜性肾炎的疗效观察[J].新疆医科大学学报，2016，39（11）：1416-1419.
[7]	王天祺，王星翘，程丽丹，等.糖皮质激素与环磷酰胺联合应用治疗肾病综合征的疗效评价[J].海峡药学，2016，28（10）：163-164.
[8]	向慧.环磷酰胺与雷公藤多苷治疗肾病综合征效果对比[J].延边医学，2015，（9）：169-170.
[9]	陈玉莲.环磷酰胺与雷公藤治疗肾性蛋白尿的疗效比较[J].齐齐哈尔医学院学报，2015（8）：1173-1174.
[10]	骆丽，雷兆锦，LUO Li，等.雷公藤多苷与环磷酰胺治疗肾病综合征有效性和安全性的Meta分析[J].海峡药学，2016，（7）：82-85.
[11]	郭鹏.雷公藤多苷与环磷酰胺治疗肾病综合征的效果比较[J].大家健康，2016，（2）：143.
[12]	姜艳.大剂量环磷酰胺及雷公藤治疗蛋白尿的护理体会[J].医学信息，2015，（3）：102.
[13]	李娜，崔娟.雷公藤多苷联合环磷酰胺对类风湿关节炎患者血清VEGF、VEGFR2表达水平的影响[J].慢性病学杂志， 2017，（1）：72-74.
[14]	王润秀，曹春瑜，汤显湖.雷公藤多甙和环磷酰胺治疗膜性肾病的效果对比[J].实用医学杂志，2016，32（10）：1726-1727.
[15]	彭洪军，夏正坤.NPHS2基因突变导致激素耐药型肾病综合征 1例[J].发育医学电子杂志，2015，（3）：170-171.
[16]	陈超阳，盛晓燕，周颖，等.他克莫司治疗原发性肾病综合征的疗效和安全性的Meta分析[J].中国新药杂志，2015，（1）：64-73.
[17]	刘倩.多靶点治疗对难治性成人肾病综合征肾功能的临床研究[J].西南国防医药，2016，26（5）：511-513.
[18]	刘洁，苏秀霞，陈云爽，等.难治性肾病综合征致急性肾衰竭诊治分析[J].临床误诊误治，2016，（b10）：18-20.