笑气、咪达唑仑与芬太尼联用在无痛胃肠镜检查中的应用效果

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Abstract Objective To investigate the application effect of Nitrous Oxide, Midazolam and Fentanyl in painless gastroenteroscopy. Methods A total of 240 patients who received gastro-colonoscopy in Longhua District People′s Hospital of Shenzhen from August 2016 to August 2017 were selected as the research subjects. According to the method of gastro-colonoscopy, the patients were divided into gastroscopy group (120 cases) and colonoscopy group (120 cases). Gastroscopy group was divided into P group, X group, MF group and MFX group according to random number table method, with 30 cases in each group. Colonoscopy group was divided into P′ group, X′ group, MF′group and MFX′group according to random number table method, with 30 cases in each group. Group P and P′received general endoscopy, group X and X′ received Nitrous Oxide sedation, group MF and MF′received Midazolam combined with Fentanyl sedation, and group MFX and group MFX′ received Nitrous Oxide combined with Midazolam and Fentanyl sedation. The changes of heart rate (HR), blood pressure,blood oxygen saturation (SpO2), sedative effect, adverse events of gastroscopy and pain degree of colonoscopy were compared between four groups respectively of gastroscopy and colonoscopy. Results ①In gastroscopy, HR, SBP and DBP in the four groups were higher than before, and SpO2 was lower than before, the differences were statistically significant (P<0.05). HR, SBP, DBP and SpO2 in the four groups all recovered to their pre-inspection levels. The sedative effect of MFX group was better than that of MF group and X group, the difference was statistically significant (P<0.05). The incidence of adverse events in group X, MF and MFX was lower than that in group P, the difference was statistically significant (P<0.008). ②In colonoscopy, HR in P′group was higher than before, the difference was statistically significant (P<0.05). There was no significant difference in SBP, DBP and SpO2 in each group (P>0.05), and they all recovered to the pre-examination level after examination. There was no significant difference in the sedative effect of X′group, MF′ group and MFX′group (P>0.05). The analgesic efficiency of MF′group and MFX′ group was higher than that of P′group, the differences were statistically significant (P<0.008). Conclusion In painless gastroenteroscopy, the combination of Nitrous Oxide, Midazolam and Fentanyl has a good sedative and analgesic effect, which is worth popularizing clinically.

Key words： Nitrous Oxide Midazolam Fentanyl Painless gastroenteroscopy

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	Articles by authors
	LI Jun-da
	DONG Si-chao
	YANG Ru-xiao
	SHEN Jian-gang
	HUANG Jin-wen
	LI Ruo-qun
	FU Zhao-xia
	HU Xian-fu

Cite this article:

LI Jun-da,DONG Si-chao,YANG Ru-xiao, et al. Application effect of Nitrous Oxide, Midazolam combined with Fentanyl in painless gastroenteroscopy[J]. 中国当代医药, 2021, 28(21): 144-148.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I21/144

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