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| Observation on the effect of high volume hem of iltration in the treatment of severe septic shock and the improvement of organ function |
| GONG Zhen-bin SHI Yun-di SHU Hai-lin GU Ling▲ |
| Department of Critical Care Medicine, Mindong Hospital of Ningde City |
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Abstract Objective To explore the effect of high volume hem of iltration in the treatment of severe septic shock and the improvement of organ function. Methods A total of 168 patients with severe septic shock admitted to Mindong Hospital of Ningde City were selected from January 2017 to October 2020 as research objects and divided into group A,group B and group C, with 56 cases in each group. Group A was treated with high volume hem of iltration under 6 hours of fluid resuscitation, group B was treated with high volume hem of iltration after 6 hours of fluid resuscitation,group C was treated with routine fluid resuscitation. The organ function, multiple organ dysfunction syndrome (MODS)score, acute physiology and chronic health evaluation (A-PACHEⅡ) score, serum levels of inflammatory factors before and after treatment and ICU hospitalization days, total hospitalization days, and 28 days mortality were compared among the three groups. Results After treatment, the alanine aminotransferase (ALT) and blood urea nitrogen (BUN) of group A were lower than those of group B and group C, and the arterial oxygenation index of group A was higher than that of group B and group C, the differences were statistically significant (P<0.05). After treatment, the MODS score and A-PACHEⅡscore of group A were lower than those of group B and group C, the differences were statistically significant (P<0.05). The levels of tumor necrosis factor-α (TNF-α) and C reactive protein (CRP) of group A were lower than those of group B and group C, the differences were statistically significant (P<0.05). ICU hospitalization days and total hospitalization days of group A were shorter than those in group B and group C, and the differences were statistically significant (P<0.05). There was no statistically significant difference of the 28 days mortality between the three groups(P>0.05). Conclusion Early high-volume hem of iltration to treat severe septic shock could promote the improvement of organ function, reduce the body′s inflammatory response, and promote the patient′s speedy recovery.
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