尘螨过敏性变应性鼻炎儿童肺功能异常的危险因素分析

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Abstract Objective To investigate the risk factors of abnormal lung function in children with dust mite allergic rhinitis (AR). Methods A total of 128 children with dust mite AR without asthma who were diagnosed in the Department of Pediatrics in Zhongshan Bo′ai Hospital Affiliated to Southern Medical University from November 2019 to April 2020 were selected as the research objects. Patients were divided into abnormal pulmonary function group (40 cases) and normal group (88 cases) according to the results of pulmonary function. The relation between abnormal lung function and gender, age, total immunoglobulin E (IgE) levels, dust mite specific IgE (sIgE) levels and the number of allergens were analyzed. Results Univariate analysis results showed that there were significant differences in the course of disease, onset time and severity of symptoms between the abnormal pulmonary function group and the normal group (P<0.05). Multivariate analysis showed that the course of disease was 3-5 years (β=1.186, OR=3.273, 95%CI=1.123-9.536), the course of disease was 5 years (β=1.551, OR=4.714, 95%CI=1.374-16.175), and the severity of symptoms was moderate and severe (β=1.531, OR=4.625, 95%CI=1.303-16.414) and persistent onset of symptoms (β=1.019, OR=2.769, 95%CI=1.144-6.701) were the influential factors of abnormal lung function (P<0.05). Conclusion Some children with dust mite AR have abnormal lung function. Children with long course, persistent, moderate-severe AR are higher probability to have abnormal lung function. There are no significant correlation between abnormal lung function and total IgE levels, sIgE levels and the number of positive SPTs.

Key words： Allergic rhinitis Lung function Risk factors Children

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	RONG Jia-yan
	WANG Gui-lan
	LIU Xiang-teng
	HUANG Juan
	CHEN Ang
	LIN Jia-biao
	WEI Ke-ying

Cite this article:

RONG Jia-yan,WANG Gui-lan,LIU Xiang-teng, et al. Risk factors analysis of abnormal lung function in children with dust mite allergic rhinitis[J]. 中国当代医药, 2021, 28(16): 8-11转16.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I16/8

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