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| Meta-analysis of traditional Chinese herbal medicine decoction combined with lifestyle interventions in the treatment of impaired glucose regulation |
| LI Ting-ting1 ZHANG Hong1▲ LI Wei |
1. Department of Science and Education, Fangshan Hospital Beijing University of Traditional Chinese Medicine, Beijing 102400, China;
2. Department of Pulmonary Disease, Fangshan Hospital Beijing University of Traditional Chinese Medicine, Beijing 102400, China |
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Abstract Objective To assess curative effects and the safety of traditional Chinese herbal medicine decoction combined with lifestyle interventions for impaired glucose regulation (IGR).Methods The Chinese and English databases were searched, and the search time limit was from January 1, 2016 to August 21, 2020. Randomized controlled trials of traditional Chinese medicine compound decoction combined with lifestyle intervention in the treatment of IGR were collected. After screening, data extraction, risk of bias and quality assessment, RevMan 5.3 was used for meta-analysis.Results A total of 8 RCTs including 666 patients were included. Meta-analysis showed that fasting blood glucose(FBG) [MD=-0.68, 95%CI (-0.94, -0.43), P<0.000 01], 2 h postprandial blood glucose (2 h PBG) [MD=-0.87, 95%CI(-1.15, -0.58), P<0.000 01], glycosylated hemoglobin (HbA1c) [MD=-0.42, 95%CI (-0.62, -0.22), P<0.0001], fasting insulin (FINS) [MD=-1.85, 95%CI (-2.64, -1.06), P<0.000 01], total cholesterol (TC) [MD=-0.75, 95%CI (-1.09, -0.41), P<0.0001], triglyceride (TG) [MD=-0.78, 95%CI (-1.08, -0.48), P<0.000 01], body mass index (BMI) [MD=-1.71, 95%CI(-2.49, -0.94), P<0.0001] in experimental group were lower than control group. Only one study reported adverse reactions. Conclusion Based on the current clinical evidence, traditional Chinese herbal medicine decoction combined with lifestyle interventions for IGR might be superior in reducing the level of FBG、2 h PBG、HbA1c、FINS、TC and TG than only lifestyle interventions. However, due to the low quality of literature and publication bias, high-quality clinical researches are still needed.
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