女性生殖道人乳头瘤病毒基因分型与宫颈病变相关性分析

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Abstract Objective To study the correlation between Human papillomavirus(HPV)genotyping in female genital tract and cervical lesions.Methods From February 2015 to February 2020,a total of 648 patients with cervical biopsy in Chaozhou People′s Hospital Affiliated to Shantou University Medical College were selected and divided into group A(124 patients with high-grade squamous intraepithelial lesions),group B(308 patients with low-grade squamous intraepithelial lesions)and group C(216 patients with cervicitis)according to the degree of cervical lesions.HPV genotyping was performed in all patients to analyze the correlation between HPV genotypes and cervical lesions.Results The results of HPV genotyping showed that 105 patients were HPV positive among 648 patients,and the HPV positive rate was 16.20%.Among them,41 cases were HPV positive in group A,53 cases were HPV positive in group B,11 cases were HPV positive in group C.The HPV subtypes with the highest infection rate were HPV 52,16,81,58,68,53,33,18 and 39.The number of HPV positive,high-risk HPV(HR-HPV)and multi subtype infection in group A was higher than that in group B and group C,and the number of HPV positive,HR-HPV and multi subtype infection in group B was higher than that in group C(P＜0.05).The results of multivariate analysis showed that HPV infection(β=0.053,OR=1.763,95%CI=1.332-2.245)and HR-HPV infection(β=0.078,OR=2.452,95%CI=1.502-3.547)were risk factors for cervical cancer(P＜0.05).Conclusion HPV infection can increase the risk of cervical lesions in women,and HRHPV infection is an independent risk factor for cervical cancer.

Key words： Human papillomavirus Cervical lesions Genotype Correlation

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	Articles by authors
	CHEN Xin-Yao
	ZHANG Jian
	DING Yan-jia
	MO Huan-tong

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CHEN Xin-Yao,ZHANG Jian,DING Yan-jia, et al. Analysis of the relationship between human papillomavirus genotyping in female genital tract and cervical lesions[J]. 中国当代医药, 2021, 28(14): 181-183转187.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I14/181

[1]	Li XM，Luo XG，He JF，et al.Induction of apoptosis in human cervical carcinoma HeLa cells by active com pounds from Hypericumascyron L[J].Oncol Lett，2018，15（3）：3944-3950.
[2]	叶建红，陈雪红，包丽丽,等.HPV E6/E7 mRNA及HPV L1蛋白表达与宫颈病变的关系及其诊断价值[J].中国妇幼健康研究，2018，29（2）：170-173.
[3]	段律芳，杜辉，肖爱民，等.Cobas 4800 HPV检测的Ct值反映的型别特异性HR-HPV亚型病毒载量与子宫颈病变关系的研究[J].中华妇产科杂志，2019，54（7）：458-463.
[4]	周晖，彭永排，俞进，等.《2014年NCCN宫颈癌临床实践指南》解读[J].实用妇产科杂志，2014，30（6）：422-425.
[5]	葛雪飞,耿力.重视女性生殖道微生态与宫颈病变关系的研究[J].中华检验医学杂志,2018,41（4）：267-269.
[6]	Li H，Ruan WJ，Liu LQ，et al.Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism[J].Chin Med J（Engl），2019，132（8）：948-956.
[7]	庞亚丹，金丽，叶利群.探讨女性生殖道高危型人乳头瘤病毒感染及其与宫颈癌病变的关系[J].中国性科学，2018，27（12）：42-45.
[8]	宋建东，宋静慧，于聪祥，等.影响宫颈病变患者HPV转归的多因素分析[J].中国实用妇科与产科杂志，2018，34（8）：892-897.
[9]	刘琳，沈攀，张力忆.宫颈病变内高危型HPV感染与Th细胞分化,细胞异常增殖的相关性[J].海南医学院学报，2018，24（3）：315-318.
[10]	甘露，刘瑞，魏明，等.绝经后妇女612例宫颈HPV感染与宫颈病变关系的临床研究[J].陕西医学杂志，2018，47（5）：574-576.
[11]	何佳英，舒畅.宫颈病变妇女人乳头瘤病毒感染及相关因素分析[J].中国预防医学杂志，2018，19（5）：385-387.
[12]	罗仲秋，冷平，刘祥琴，等.成都地区妇女HPV感染的流行病学特征及与宫颈病变的关系[J].国际生殖健康/计划生育杂志，2018，37（1）：49-53.
[13]	王晴，张蓓，印泽远，等.HPV分型定量检测对宫颈病变的预测价值[J].现代妇产科进展，2018，27（5）：351-354，358.
[14]	石丹丽，庞小芬，王佳丽，等.人乳头瘤病毒在宫颈病变中的感染分型及其特点[J].现代生物医学进展，2018，18（8）：1578-1582，1547.
[15]	麦雄燕，韦迪霞，袁飞飞，等.不同基因亚型人乳头瘤病毒感染与宫颈病变的关系[J].中华医院感染学杂志，2018，28（1）：121-124.