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| Effect of Dapagliflozin on neutrophil to lymphocyte ratio,platelet to lymphocyte ratio,C-reactive protein and interleukin 6 in type 2 diabetes mellitus patients with carotid atherosclerosis |
| ZHANG Yao-yi1 TIAN Chen-guang2▲ |
| Department of Endocrine,the Second Affiliated Hospital of Zhengzhou University,He′nan Province,Zhengzhou 450014,China |
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Abstract Objective To investigate the effect of Dapagliflozin on the neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),C-reactive protein(CRP)and interleukin 6(IL-6)in patients with type 2 diabetes mellitus(T2DM)with carotid atherosclerosis.Methods A total of 100 patients with T2DM complicated with atherosclerosis admitted to the Second Affiliated Hospital of Zhengzhou University from August 2019 to January 2020 were selected as the research objects.They were divided into Dap group and Con group according to the random number method,with 50 cases in each group.The patients in the Con group were treated with proglycemic regimen,and the patients in the Dap group were treated with Dapagliflozin in addition to proglycemic regimen for 20 weeks.The levels of NLR,PLR,CRP and IL-6 in the two groups before and after treatment were compared.Results Before treatment,there were no significant differences in the levels of NLR,PLR,CRP and IL-6 between the two groups(P＞0.05).After treatment,the levels of NLR,PLR,CRP and IL-6 in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,the levels of NLR,PLR,CRP and IL-6 in Dap group were lower than those in Con group,and the differences were statistically significant(P＜0.05).Conclusion Dapagliflozin can reduce NLR,PLR,CRP and IL-6 levels in patients with T2DM and arteriosclerosis,and improve the body′s low inflammatory state.
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