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| Effects of Compound Guaiacol Potassium Sulfonate Oral Solution on acute bronchitis in children |
| LIU Jia |
| 湖北省荆州市第三人民医院儿科，湖北荆州 434000 |
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Abstract Objective To investigate the effect of Compound Guaiacol Potassium Sulfonate Oral Solution on children with acute bronchitis.Methods A total of 84 children with acute bronchitis treated in the Third People′s Hospital of Jingzhou City from January 2019 to January 2020 were selected as the research subjects.According to random number table method,they were divided into control group and observation group,with 42 cases in each group.The control group was given Ribavirin Injection intravenously,and the observation group was given Compound Guaiacol Potassium Sulfonate Oral Solution on this basis.After 10 d of treatment,the differences in efficacy,time of disappearance of clinical symptoms and incidence of adverse drug reactions,as well as the differences in serum inflammatory indexes(C-reactive protein[CRP],interlenkin-6[IL-6]and tumor necrosis factor[TNF]-α)between the two groups before and after 10 d of treatment were compared.Results After 10 d of treatment,the efficacy in the observation group was better than that in control group,and the total clinical effective rate was higher than that in the control group,and the differences were statistically significant(P＜0.05).The disappearance times of cough,high fever,expectoration and lung rales in the observation group were shorter than those in control group(P＜0.05).There was no significant difference in the total incidence rate of adverse drug reactions of gastrointestinal reactions,dizziness and somnolence between the two groups(P＞0.05).Before treatment,there were no significant differences in serum CRP,IL-6 and TNF-α between the two groups(P＞0.05).After 10 d of treatment,CRP,IL-6 and TNF-α in the two groups were lower than those before treatment,and serum CRP,IL-6 and TNF-α in observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Compound Guaiacol Potassium Sulfonate Oral Solution in the adjuvant treatment of children with acute bronchitis is safe,reliable and effective in accelerating the disappearance of clinical symptoms and improving the related indicators of inflammatory factors,which has clinical application value.
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| [1] |
魏学琴，杨怡.小儿肺咳颗粒联合环酯红霉素治疗小儿急性支气管炎的临床研究[J].现代药物与临床，2020，35（5）：959-962.
|
| [2] |
王少燕.肺力咳合剂联合孟鲁司特治疗小儿急性支气管炎49例临床研究[J].中国药物与临床，2019，19（12）：2060-2062.
|
| [3] |
孙婷婷，潘曌曌，于洋，等.痰热清注射液治疗小儿急性支气管炎疗效Meta分析[J].创伤与急危重症病医学，2019，7（3）：187-189.
|
| [4] |
胡亚美，江载芳.诸福棠实用儿科学[M].7版.北京：人民卫生出版社，2002：746.
|
| [5] |
赵会茹，吴文先.小儿柴桂退热颗粒治疗小儿急性支气管炎伴发热临床研究[J].陕西中医，2019，40（4）：431-434.
|
| [6] |
王亚萍，杨银定.中西医结合治疗小儿急性支气管炎临床观察[J].西部中医药，2017，30（1）：77-78.
|
| [7] |
申丹，张明瑛.小儿肺热清颗粒联合头孢呋辛酯治疗小儿急性支气管炎的临床研究[J].现代药物与临床，2020，35（3）：503-506.
|
| [8] |
朱秋玲，严鹏科，李军.抗病毒口服液联合利巴韦林治疗小儿急性上呼吸道感染的疗效观察[J].检验医学与临床，2016，13（22）：3255-3256.
|
| [9] |
毛晨梅，黄莹莹，杨梦婕，等.夜咳灵口服液的稳定性观察[J].江苏医药，2011，37（11）：1347-1348.
|
| [10] |
姚春根.盐酸布桂嗪联合盐酸异丙嗪辅助治疗顽固性癌痛的临床疗效观察[J].安徽医药，2016，20（7）：1398-1400.
|
| [11] |
那开宪.久服复方甘草片应警惕低血钾发生[J].中国临床医生杂志，2019，47（7）：757-758.
|
| [12] |
吴坚，吕世文.孟鲁司特钠辅助治疗小儿支气管哮喘的疗效及对免疫功能和炎症细胞因子水平的影响[J].重庆医学，2020，49（12）：1979-1983.
|
| [13] |
张军.小儿柴桂退热颗粒辅助治疗小儿急性上呼吸道感染的效果观察[J].中国妇幼保健，2017，32（14）：3226-3238.
|
| [14] |
焦凤兰，杨文东.雾化吸入治疗小儿支气管哮喘急性发作的临床疗效及C-反应蛋白水平观察[J].临床肺科杂志，2012，17（5）：919-920.
|
| [15] |
刘丹，钟媛，杨帆.血清C反应蛋白、降钙素原及纤维蛋白原对老年肺部感染的预测价值[J].实用医院临床杂志，2020，17（4）：179-181.
|
|
|
|
