NRP-2表达水平与胃癌临床病理特征及预后的相关性研究

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Abstract Objective To observe the clinicopathological characteristics,prognosis and neuropilin-2(NRP-2)expression of gastric cancer patients,and to analyze the relationship between NRP-2 expression and clinicopathological characteristics and prognosis of gastric cancer patients.Methods A total of 120 gastric cancer patients who were admitted to Liaoyang Central Hospital from June 2016 to December 2017 were selected as research objects.All patients were treated with radical gastric cancer surgery.The clinicopathological characteristics and prognosis of the patients were recorded.The predictive value of serum NRP-2 level for different clinicopathological characteristics and prognosis of gastric cancer was observed.Results Among all 120 patients with gastric cancer,38 patients had lower stomach cancer,55 patients had serous and extraserous infiltration,88 patients had lymph node metastasis,and 57 patients had TNM stage Ⅲ.There were 49 cases of recurrence,and the recurrence rate was 40.83%.There were no statistically significant difference in serum NRP-2 levels between different disease sites and TNM stages(P>0.05).The serum NRP-2 level of the patients who had serosal and extraserous infiltration,lymph node metastasis,postoperative recurrence were higher than those of patients who had mucosa and submucosa+muscular layer,no lymph node metastasis,and no recurrence,the differences were statistically significant(P＜0.05).The receiver operating characteristic(ROC)curve results showed that the serum NRP-2 level predicted in patients with gastric cancer,the area under curve(AUC)of serosal and extraserous,lymph node metastasis,and recurrence risk are all>0.80,and the predictive value was ideal.Conclusion NRP-2 may be involved in the occurrence and progression of gastric cancer,and is related to the malignant biological behavior of gastric cancer,and the high expression of NRP-2 can lead to poor prognosis of gastric cancer.

Key words： Gastric cancer Neuropilin-2 Prognosis Pathological features

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GAO Yan-hua. Study on the correlation between the expression of NRP-2 and the clinicopathological characteristics and prognosis of gastric cancer[J]. 中国当代医药, 2021, 28(13): 42-45.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I13/42

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