慢性阻塞性肺病血清IgG亚型水平与急性加重及住院风险的关系

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Abstract Objective To analyze the relationship between serum immunoglobulin G(IgG)subtype levels of chronic obstructive pulmonary disease(COPD)and acute exacerbation and hospitalization risk.Methods A total of 60 patients with stable COPD in Shangrao Municipal Hospital of Jiangxi Province from June 2019 to February 2020 were selected as the observation group,according to the IgG4 level of the patients,19 COPD patients whose IgG4 level was lower than the normal level and accompanied with more than 2 acute attacks in 1 year were classified as the low group,41 COPD patients with normal IgG4 level were included in the normal group.In addition,20 patients who had no disease in this hospital during the same period were selected as the control group.The serum IgG4 level was compared between the observation group and control group,and the relationship between serum IgG4 level and acute exacerbation and hospitalization risk was analyzed.Results The IgG4 level of the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05).The frequency of acute exacerbation and the frequency of hospitalization in the low group before intervention were higher than those in the normal group,and the differences were statistically significant(P＜0.05).After intervention,there were no significant differences in the frequency of acute exacerbation and the frequency of hospitalization between the low group and the normal group(P＞0.05).Conclusion Low serum IgG subtype levels in patients with COPD will increase the frequency of acute exacerbation and the risk of hospitalization.The application of Thymalfasin can effectively reduce the number of acute exacerbations and the frequency of hospitalization in COPD patients with low IgG subtype levels.Therefore,the serum IgG subtype has a certain early warning effect on the acute onset of COPD.

Key words： Chronic obstructive pulmonary disease Immunoglobulin G subtypes Acute exacerbation period Hospitalization risk Thymalfasin

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	Articles by authors
	SHEN Pei-lei
	SUN Pan-bo
	LUO Bin

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SHEN Pei-lei,SUN Pan-bo,LUO Bin. Relationship between serum IgG subtype levels of chronic obstructive pulmonary disease and acute exacerbation and hospitalization risk[J]. 中国当代医药, 2021, 28(14): 43-46.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I14/43

[17]	潘燕蝶，潘小丹，李洁，等.慢性阻塞性肺疾病继发肺部感染的炎性因子及TLR7/IL-23/IL-17信号通路作用[J].中华医院感染学杂志，2020，30（7）：994-998.
[18]	丁树和.免疫球蛋白G亚型检测在小儿反复呼吸道感染中的应用[J].中国实验诊断学，2017，21（5）：872-873.
[1]	陈泳康，姚桂谊，谭志坚.慢性阻塞性肺疾病患者伴发自杀观念的发生率及相关危险因素分析[J].中国当代医药，2019，26（22）：181-184.
[2]	韦瑞含，罗晶丹，王毅.小儿肺炎支原体肺炎发病机制与血清免疫球蛋白A、免疫球蛋白M、免疫球蛋白G水平相关性研究[J].临床军医杂志，2018，46（4）：454-455.
[3]	葛均波，徐永健，王辰.内科学[M].北京：人民卫生出版社，2018：21-27.
[4]	Strijbos E，Huijbers MG，van Es IE，et al.A prospective，placebo controlled study on the humoral immune response to and safety of tetanus revaccination in myasthenia gravis[J].Vaccine，2017，35（46）：6290-6296.
[5]	余建华.慢性阻塞性肺疾病急性加重期免疫学指标与肺功能的相关分析[J].检验医学与临床，2018，15（9）：1266-1267，1270.
[6]	陈立文，李崇文.不同病程COPD患者免疫功能的临床分析[J].中国实验诊断学，2017，21（1）：32-34.
[7]	施静，罗勇，李刚，等.频发急性加重COPD表型患者临床特征分析[J].临床肺科杂志，2018，23（9）：1638-1641.
[8]	武元星，黄立学，朱光发.慢性阻塞性肺疾病急性加重患者免疫球蛋白的表达及临床意义[J].中国急救医学，2018，38（4）：294-297.
[9]	陈纯，唐春利，吴忠辉，等.慢性阻塞性肺疾病呼吸道病毒感染患者肺功能与血清免疫球蛋白轻链的相关性研究[J].河北医药，2018，40（15）：2344-2346.
[10]	Xiong Y，Gao S，Luo G，et al.Increased Circulating Autoantibodies Levels of IgG，IgA，IgM Against Cytokeratin 18 and Cytokeratin 19 in Chronic Obstructive Pulmonary Disease[J].Arch Med Res，2017，48（1）：79-87.
[11]	张延峰，王栋梅，杨琳东.肺炎支原体肺炎患儿补体,免疫球蛋白含量与炎性应激反应的相关性分析[J].中国临床医生杂志，2019，47（12）：1474-1477.
[12]	王薇，李彦青.血清免疫球蛋白、T细胞亚群水平及维生素D与婴幼儿反复呼吸道感染的相关性分析[J].中国医师杂志，2018，20（8）：1205-1207.
[13]	高兵，李松，马虹，等.过敏性哮喘患儿外周血Th17/Treg比值变化及其与呼吸功能、免疫球蛋白的相关性[J].疑难病杂志，2019，18（6）：594-596，601.
[14]	涂娟娟，何建云.支原体肺炎患儿血清补体、免疫球蛋白含量与炎症应激反应的相关性分析[J].海南医学院学报，2018，24（11）：1097-1100.
[15]	卢敬东.血清免疫球蛋白表达与咳嗽变异性哮喘患儿预后相关性分析[J].中国医药导刊，2017，19（12）：1299-1302.
[16]	龚璐璐.FLC在吸烟肺功能正常者和慢阻肺患者肺部炎症机制中的作用及临床意义[J].临床肺科杂志，2017，22（10）：1809-1812.