间充质干细胞在鼓膜再生组织工程中的应用进展

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Abstract Eardrum is an important structure of hearing conduction and a protective barrier of the middle ear.Perforation may causes hearing loss,otorrhea and even serious complications.Trauma,middle ear infection and tympanostomy are the main causes of tympanic membrane perforation.Otolaryngologists will close the perforated eardrum via a surgery intervention.However,due to the limitations of surgical technical requirements,high costs,and surgical complications,it is necessary to find out a better alternative to surgical methed.With respect to this issue,the tissue engineering has been applied in experimental and clinical studies,including the biocompatible scaffolds,growth factors and stem cells to restore and improve the function of the eardrum.Mesenchymal stem cells(MSCs)are progenitors that can differentiate into a variety of cell types,can be isolated from a variety of tissues,and facilitiy to be cultured in vitro.Due to its biological characteristics,MSCs have attracted much attention in the treatment of many diseases.Studies have shown that the application of MSCs alone or in combination with biomaterials at the site of tympanic membrane rupture may promote the migration and proliferation of keratinocytes and thereby promote the closure of perforated tympanic membrane.This paper reviews the application of MSCs in tympanic membrane regeneration and its potential mechanism,and discusses the existing problems in the application of MSCs.

Key words： Tympanic membrane Perforation Regeneration Mesenchymal stem cells Tissue engineering

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	Articles by authors
	LYU Cui-ting
	HU Yi
	SHEN Yi

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LYU Cui-ting,HU Yi,SHEN Yi. Progress in application of mesenchymal stem cells in tissue engineering of tympanic membrane regeneration[J]. 中国当代医药, 2021, 28(14): 35-38转46.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I14/35

[1]	Ott MC，Lundy LB.Tympanic membrane perforation in adults.How to manage，when to refer[J].Postgrad Med，2001，110（5）：81-84.
[2]	Teh B，Marano R，Shen Y，et al.Tissue engineering of the tympanic membrane[J].Tissue Eng Part B Rev，2013，19（2）：116-132.
[3]	O′Connor K，Tam M，Blevins N，et al.Tympanic membrane collagen fibers：a key to high-frequency sound conduction[J].Laryngoscope，2008，118（3）：483-490.
[4]	Friedenstein A，Chailakhjan R，Lalykina K.The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells[J].Cell Tissue Kinetics，1970，3（4）：393-403.
[5]	Ding D，Shyu W，Lin S.Mesenchymal stem cells[J].Cell Transplant，2011，20（1）：5-14.
[6]	Castro-Manrreza M，Montesinos J.Immunoregulation by mesenchymal stem cells：biological aspects and clinical applications[J].J Immunol Res，2015，2015：394917.
[7]	Wang X，Gu H，Qin D，et al.Exosomal miR-223 Contributes toMesenchymalStemCell-ElicitedCardioprotectioninPolymicrobial Sepsis[J].Sci Rep，2015，8（5）：13721.
[19]	黎欢，胡益，姚旭，等.鼓膜组织工程学研究进展[J].中国现代医生，2019，57（8）：164-168.
[22]	Ozbolat IT，Hospodiuk M.Current advances and future perspectives in extrusion-based bioprinting[J].Biomaterials，2016，76：321-343.
[8]	Lazarus HM，Haynesworth SE，Gerson SL，et al.Ex vivo expansion and subsequent infusion of human bone marrowderived stromal progenitor cells（mesenchymal progenitor cells）：implications for therapeutic use[J].Bone Marrow Transplant，1995，16（4）：557-564.
[9]	Choudhery M，Badowski M，Muise A，et al.Comparison of human mesenchymal stem cells derived from adipose and cord tissue[J].Cytotherapy，2013，15（3）：330-343.
[10]	Jiang Y，Vaessen B，Lenvik T，et al.Multipotent progenitor cells can be isolated from postnatal murine bone marrow，muscle，and brain[J].Exp Hematol，2002，30（8）：896-904.
[11]	Zhao X，Yang Z，Zhang H，et al.Resveratrol Promotes Osteogenic Differentiation of Canine Bone Marrow Mesenchymal Stem Cells Through Wnt/Beta-Catenin Signaling Pathway[J].Cell Reprogram，2018，20（6）：371-381.
[12]	Camnitz P，Bost W.Traumatic perforations of the tympanic membrane：early closure with paper tape patching[J].Otolaryngol Head Neck Surg，1985，93（2）：220-223.
[13]	Rahman A，Olivius P，Dirckx J，et al.Stem cells and enhanced healing of chronic tympanic membrane perforation[J].Acta Otolaryngol，2008，128（4）：352-359.
[14]	Liew L，Chen L，Wang A，et al.Tympanic Membrane Derived Stem Cell-Like Cultures for Tissue Regeneration[J].Stem Cells Dev，2018，27（10）：649-657.
[15]	Rhee K，Lee J，Eom Y.Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression[J].Int J Sci，2015，16（12）：30015-30033.
[16]	Huang S，Lu G，Wu Y，et al.Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair[J].J Dermatol Sci，2012，66（1）：29-36.
[17]	Haddad B，Pakravan A，Konan S，et al.A systematic review of tissue engineered meniscus：cell-based preclinical models[J].Curr Stem Cell Res Ther，2013，8（3）：222-231.
[18]	Goncalves S，Bas E，Goldstein B，et al.Effects of Cell-Based Therapy for Treating Tympanic Membrane Perforations in Mice[J].Otolaryngolo Head Neck Sur，154（6）：1106-1114.
[20]	Goncalves S，Bas E，Langston M，et al.Histologic changes of mesenchymal stem cell repair of tympanic membrane perforation[J].Acta otolaryngol，2017，137（4）：411-416.
[21]	Wilcox B，Mobbs R，Wu A，et al.Systematic review of 3D printing in spinal surgery：the current state of play[J].J Spine Surg，2017，3（3）：433-443.
[23]	Jang C，Ahn S，Lee J，et al.Mesenchymal stem cell-laden hybrid scaffold for regenerating subacute tympanic membrane perforation[J].Mater Sci Eng C Mater Bio Appl，2017，72：456-463.
[24]	Ostrovidov S，Salehi S，Costantini M，et al.3D Bioprinting in Skeletal Muscle Tissue Engineering[J].Small，2019，15（24）：e1805530.
[25]	Bakht Khosh Hagh H，Farshi Azhar F.Reinforcing materials for polymeric tissue engineering scaffolds：A review[J].J Biomed Mater Res B Appl Biomater，2019，107（5）：1560-1575.
[26]	Dominici M，Le Blanc K，Mueller I，et al.Minimal criteria for defining multipotent mesenchymal stromal cells[J].Cytotherapy，2006，8（4）：315-317.
[27]	Khasawneh RR，Abu-El-Rub E，Serhan AO，et al.Cross talk between 26S proteasome and mitochondria in human mesenchymal stem cells′ability to survive under hypoxia stress[J].J Physiol Sci，2019，69（6）：1005-1017.
[28]	Amariglio N，Hirshberg A，Scheithauer BW，et al.Donorderived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient[J].PLoS Med，2009，6（2）：e1000029.
[29]	Miyazaki Y，Oda T，Mori N，et al.Adipose-derived mesenchymal stem cells differentiate into pancreatic cancerassociated fibroblasts in vitro[J].FEBS Open Bio，2020，10（11）：2268-2281.