降钙素原、C反应蛋白与线粒体DNA水平检测在老年脓毒症多器官功能衰竭病情评估中的应用

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Abstract ObjectiveTo explore the application values of procalcitonin(PCT),C-reactive protein(CRP)and mitochondrial DNA(mt-DNA)level test in the assessment of multiple organ dysfunction in multiple organ dysfunction in elderly(MODSE)patients with sepsis.MethodsFrom January 2014 to December 2016,62 elderly patients with sepsis admitted into our hospital were selected as research objects.Among them,29 patients complicated with organ failure were classified into the failure group,and the rest was categorized into the non-failure group.Meanwhile,another group of 30 healthy participants after physical examinations was classified into the control group.The differences of PCT,CRP,and mt-DNA levels were compared.ResultsThe levels of PCT,CRP and mt-DNA levels in sepsis patients were significantly higher than those in the control group (P＜0.05).The levels of mt-DNA and PCT in the failure group were significantly higher than those in the non-failure group(P＜0.05).But,there was no great difference in CRP between the failure group and the non-failure group (P＞0.05).According to the conditions of organ failure,the patients were further divided into the single-organ failure group (n=11),the double-organ failure group (n=9),and the three or above organ failure group(n=9).With the increased number of failure organs,the levels of mt-DNA and PCT were greatly increased,which were displayed statistical significance between inter-group comparison(P＜0.05),the CRP level was not in a statistical difference after comparison(P＞0.05).ConclusionProcalcitonin,CRP and mt-DNA all can indicate the occurrence of sepsis in elderly patients.Test of PCT and mt-DNA levels can not only be used in the diagnosis of sepsis,but also to evaluate the MODSE patients with sepsis,which is worthy of clinical promotion and application.

Key words： Sepsis Multiple organ dysfunction Elderly Procalcitonin C-reactive protein Mitochondrial DNA

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	Articles by authors
	LIAO Xiao-long
	GUO Wei-xin
	WANG Zhong-hua
	LIANG Jun
	WANG Shou-hong

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LIAO Xiao-long,GUO Wei-xin,WANG Zhong-hua, et al. Application of procalcitonin,C-reactive protein and mitochondrial DNA level test in the assessment of multiple organ dysfunction in elderly patients with sepsis[J]. 中国当代医药, 2017, 24(30): 123-125.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I30/123

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