亮丙瑞林与戈舍瑞林对卵巢子宫内膜异位症术后复发及妊娠成功率的影响

Abstract
Figure/Table
References (16)
Related Citation (1)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract

ObjectiveTo investigate the effect of Leuprorelin and Goserelin on recurrence and pregnancy rates after ovarian endometriosis laparoscopic surgery.MethodsA total of 71 cases female patients with ovarian endometriosis,fertility intention and received conservative operation who treated in our hospital from June 2012 to June 2016 were retrospectively analyzed.According to the medication they received,patients were divided into three groups,including group NON(no medication,n＝26),group LEU(Leuprorelin,3.75 mg/28d,n＝24),and group GOS(Goserelin,3.6 mg/28d,n＝21).The clinical efficacy,recurrence rates after treatment,rates of successful pregnancy,alleviated rates of dysmenorrhea and incidence of adverse reaction of each group were compared.ResultsThe clinical efficiency of group NON (61.5%)was significantly lower than group LEU(70.8%)and group GOS(76.2%),and the differences were statistically significant(P＜0.05).The clinical efficiency of group LEU were compared with group GOS,and the difference was not statistically significant(P＞0.05).The successful pregnancy rate(38.5%),dysmenorrhea alleviated rate(65.3%)of group NON were significantly lower than that of group LEU(70.8%,75.0%)and group GOS(76.2%,76.2%),the differences were statistically significant(P＜0.05).The recurrence rates of group NON(46.2%)was significantly higher than group LEU(25.0%)and group GOS(28.6%),the differences were statistically significant(P＜0.05).The recurrence rate,successful pregnancy rate,dysmenorrhea alleviated rate and incidence of adverse reactions of group LEU were compared with group GOS,and the difference was not statistically significant(P＞0.05).ConclusionFor patients with ovarian endometriosis,conservative operation combined with administration of GnRH-a would effectively increase the clinical efficacy and rates of successful pregnancy after treatment,alleviate symptom of dysmenorrhea,reduce the recurrence rates and incidence of adverse reactions.While the differences between Leuprorelin and Goserelin have no statistically significant.

Key words： Ovarian endometriosis GnRH-a Leuprorelin Goserelin

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	FAN Lian-yun
	WAN Gui-ping

Cite this article:

FAN Lian-yun,WAN Gui-ping. Effect of Leuprorelin and Goserelin on recurrence and pregnancy rates after ovarian endometriosis operation[J]. 中国当代医药, 2017, 24(30): 98-101.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I30/98

[1]	Guo SW.Recurrence of endometriosis and its control[J].Hum Reprod Update，2009，15（4）：441-461.
[2]	宋菁华，鲁桦，张军，等.腹腔镜手术联合促性腺激素释放激素激动剂治疗内异症的临床研究[J].中华妇产科杂志，2013，48（8）：584-588.
[3]	袁蕾，吴琴娇，刘惜时.国产醋酸亮丙瑞林微球预防卵巢内异症囊肿术后复发的近期疗效观察[J].中华妇产科杂志，2013，48（7）：508-510.
[4]	Chiang HJ，Lin PY，Huang FJ，et al.The impact of previous ovarian surgery on ovarian reserve in patients with endometriosis[J].BMC Womens Health，2015，10（15）：74.
[5]	Soga K，Imamura H，Ikeda S.Complete laparoscopic excision of endometriosis in teenagers：Is postoperative hormonal sup-pression necessary?[J].Fert Steril，2011，95（6）：1909-1912.
[6]	Sesti F，Capozzolo T，Pietropolli A，et al.Recurrence rate of endometrioma after laparoscopic cystectomy：comparative randomized trial between post-operative hormonal suppression treatment or dietary therapy vs.placebo[J].Eur J Obstet Gynecol Reprod Biol，2009，147（1）：72-77.
[7]	Yang XH，Ji F，AiLi A，et al.Effects of laparoscopic ovarian endometriosiscystectomycombinedwithpostoperativeGnRH-a therapy on ovarian reserve，pregnancy，and outcome recurrence[J].Clin Exp Obstet Gynecol，2014，41（3）：272-275.
[8]	Zhong YJ，Zhang W，Zhang WT，et al.Efficacy and safety of GnRH-a combine with laparoscope conservative surgery in the treatment of the moderate or severe endometriosis[J].Chin J Obstet Gynecol，2013，48（3）：180-182.
[9]	Bastu E,Yasa C,Dural O，et al.Comparison of ovulation induction protocols after endometrioma resection[J].JSLS，2014，18（3），122-124.
[10]	Sritsa D，Saare M，Laisk-Podar T，et al.Pregnancy rate in endometriosis patients according to the severity of the disease after using a combined approach of laparoscopy，GnRH agonist treatment and in vitro fertilization[J].Gynecol Obstet Invest，2015，79（1）：34-39.
[11]	Morelli M，Rocca ML，Venturella R，et al.Improvement in chronic pelvic pain after gonadotropin releasing hormone analogue （GnRH-a） administration in premenopausal women suffering from adenomyosis or endometriosis：a retrospective study[J].Gynecol Endocrinol，2013，29（4）：305-308.
[12]	Khan KN．Kitajima M，Hiraki K，et al．Cell proliferation effect of GnRH agonist on pathological lesions of women with endometriosis，adenomyosis and uterine myoma[J].Hum Reprod，2010，25：2878-2890．
[13]	Huang F，Wang H，Wu M，et al.Inhibitory effect of GnRHII andGnRHIaonthestromalcellproliferationfromendometriosis patients[J].J Cent South Univ Med，2011，36（6）：554-558.
[14]	Ferrero S，Gillott DJ，Remorgida V，et al.GnRH analogue remarkably down-regulates inflammatory proteins in peritoneal fluid proteome of women with endometriosis[J].J Reprod Med，2009，54（4）：223-231.
[15]	Khan KN，Kitajima M，Hiraki K，et al.Changes in tissue inflammation，angiogenesis and apoptosis in endometriosis，adenomyosis and uterine myoma after GnRH agonist therapy[J].Hum Reprod，2010，25（3）：642-653.
[16]	Weng H，Liu F，Hu S，et al.GnRH agonists induce endometrial epithelial cell apoptosis via GRP78 down-regulation[J].J Transl Med，2014，4（12）：306.