3.0T磁共振T1WI与T1 mapping在轻度新生儿高胆红素血症诊断中的临床价值

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Abstract Objective To investigate the clinical value of T1WI and T1 mapping in the diagnosis of mild neonatal hyperbilirubinemia with 3.0T MRI. Methods From July 2018 to January 2019, 13 neonates with mild hyperbilirubinemia in the Department of Radiology of People′s Hospital of Longhua District in Shenzhen City were selected as the hyperbilirubinemia group and 17 normal neonates in the same period were selected as the normal group. T1WI and T1 mapping were performed on both neonates in the hyperbilirubinemia group and the normal group by Philips 3.0T MRI. T1 signal intensity of the bilateral globus pallidus was measured at the post-processing workstation and the mean value was calculated. T1 mapping was obtained by automatic operation using IR-TSE sequences with 8 different inversion times. T1 value of the bilateral globus pallidus were measured and the average was calculated. The difference of T1 signal intensity and T1 value between the two groups were compared, and the correlation between T1 signal intensity and T1 value of the globus pallidus with peak value of total bilirubin were analyzed separately. Results The peak value of serum bilirubin in the hyperbilirubinemia group was higher than that in the normal group, and the difference was statistically significant (P＜0.05). The T1 signal intensity in the hyperbilirubinemia group was higher than that in the normal group, and the difference was statistically significant (P＜0.05). T1 value of globus pallidum in the hyperbilirubinemia group was lower than that in the normal group, and the difference was statistically significant (P＜0.05). The T1 signal intensity of globus pallidum was positively correlated with the peak value of total bilirubin (r=0.675, P=0.000). T1 value of globus pallidum was slightly negatively correlated with the peak value of serum total bilirubin (r=-0.455, P=0.012).Conclusion The T1 signal intensity and T1 value of globus pallidus in patients with mild neonatal hyperbilirubinemia are different from those in normal neonates, and have implications for the diagnosis of early acute bilirubin encephalopathy.

Key words： Neonatal jaundice T1 signal intensity T1 value T1 mapping

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	Articles by authors
	DING Ling
	DU Jiang-qi
	ZENG Jian-bing
	WANG Xin-zheng

Cite this article:

DING Ling,DU Jiang-qi,ZENG Jian-bing, et al. Clinical value of T1WI and T1 mapping in the diagnosis of mild neonatal hyperbilirubinemia with 3.0T MRI[J]. 中国当代医药, 2020, 27(16): 175-177.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I16/175

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