口服葡萄糖耐量试验中空腹血糖水平升高妊娠期糖尿病患者的妊娠结局分析

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Abstract Objective To analyze of pregnancy outcome of gestational diabetes mellitus (GDM) patients with increased fasting blood glucose level in 75 g oral glucose tolerance test OGTT. Methods A total of 450 cases of pregnant women with increased fasting blood glucose of GDM who were received standard prenatal examination and delivered in our hospital from January 2015 to January 2018 were selected, and grouped according to the results of fasting, 1 and 2 hours after taking the glucose in OGTT test, only fasting blood glucase increased to GDM group Ⅰ, the fasting combined with elevalted blood glucose at any other time point as the GDM group Ⅱ, all three time points were elevated as GDM group Ⅲ. A total of 450 healthy pregnant women who were examined at the same time were selected for a control group, the pregnancy outcomes of the two groups were compared. Spearman correlation was used to analyze the relationship between different phase blood glucose and neonatal weight. Results The incidences of premature delivery,large for gestational age (LGA), cesarean section, and hypertensive disorder complicating pregnancy in the study group were higher than those in the control group (P＜0.05)； there were significant differences in the comparison of LGA, insulin usage and cesarean section (P＜0.05), that was the complications increased with the growing abnormal blood glucose levels. There were no differences in premature delivery and hypertensive discorders comlicating pregnancy in the three groups (P＞0.05). The incidence of LGA in GDM group Ⅲwas higher than that of GDM group Ⅰ, and the difference was statistically significant (P＜0.05). There was no significant difference compared with GDM group Ⅱ(P＞0.05).Comparison of insulin usage rate, GDM group Ⅲwas higher than that of GDM groupⅠ, and the difference was statistically significant (P＜0.05). Spearman correlation analysis result showed that fasting plasma glucose was positively correlated with neonatal weight (r=0.122, P＜0.01), that neonatal weight was on the rise with the increase of fasting blood glucose. Conclusion The incidence of adverse pregnancy outcome is significantly increased in GDM patients with OGTT multipoint abnormal blood glucose. The fasting blood glucose level is important for the prediction of pregnancy outcome and neonatal weight. Clinical management should be individualized based on OGTT abnormalities status .

Key words： Gestational diabetes mellitus Oral glucose tolerance test Pregnant outcome Birth weight

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	LIU Ji-qun
	DONG Chen
	JIAN Jie-ying

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LIU Ji-qun,DONG Chen,JIAN Jie-ying. Analysis of pregnancy outcome of gestational diabetes mellitus patients with increased fasting blood glucose level in oral glucose tolerance test[J]. 中国当代医药, 2020, 27(16): 120-123.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I16/120

[1]	董瑞卿，洪莉．早期妊娠糖脂代谢指标检测对妊娠期糖尿病及新生儿结局的预测价值[J]．中国妇幼保健，2016，31（2）：246-248．
[2]	苏日娜，朱微微，魏玉梅，等.北京地区妊娠期糖尿病发病情况及妊娠结局的回顾性调查[J].中华围产医学杂志，2005，19（5）：330-335．
[3]	Scholtens Denise M，Muehlbauer Michael J，Daya Natalie R，et al.Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy[J].Diabetes Care，2014，37（1）：158-166.
[4]	严励，何扬，薛声能，等．胰岛β 细胞分泌功能评估指标的比较-186 例不同糖耐量者葡萄糖耐量试验资料分析[J]．中华内分泌代谢杂志，2005，21（6）：503-505．
[5]	李点英，彭靖斐，孟涛.75 g OGTT 不同时间点血糖指标妊娠期糖尿病产妇妊娠结局的关系分析[J].实用妇产科杂志，2019，35（4）：289-293.
[6]	张建华，李章平，陈芳，等.口服葡萄糖耐量试验曲线下面积在妊娠期糖尿病中的应用[J]．内科急危重症杂志，2017，23（5）：375-378．
[7]	魏玉梅，杨慧霞．妊娠期糖尿病不同诊断标准适宜性的比较[J]．中华妇产科杂志，2011，46（8）：578-581.
[8]	Nicholson W，Wang NY，Baptiste-Roberts K，et al.Association between adiponectin and tumor necrosis factor alphalevelsat eight to fourteen weeks gestation and maternal glucose tolerance：the parity，inflammation，and diabetes study[J].J Womens Health （Larchmt），2013，22（3）：259-266.
[9]	怀莹莹，李晨波.妊娠期糖尿病75 g OGTT 不同时点血糖异常与妊娠结局的相关性分析[J].中国妇产科杂志，2011，46（8）：578-581.
[10]	王成书，魏玉梅，杨慧霞.妊娠期糖尿病孕妇不同血糖指标异常与妊娠结局的关系[J].中华妇产科杂志，2013，48（12）：899-902.
[11]	鲁花丽，于坚伟，程雪琴.妊娠期糖尿病不同血糖水平孕妇的临床特点与妊娠结局分析[J].中国计划生育和妇产科，2016，8（5）：12-15.
[12]	陈晨，孙丽洲.妊娠期葡萄糖耐量试验血糖值与新生儿出生体重的关系[J].中华围产医学杂志，2012，15（8）：502-504.
[15]	黄兆明，卢锦娥.血糖水平控制正常妊娠期糖尿病孕妇的围产结局分析[J].中华妇产科学杂志，2018，53（9）：625-629.
[18]	刘石萍，邢会美，苏世萍，等.单纯空腹血糖升高的妊娠期糖尿病患者的妊娠结局及其影响因素[J].中华围产医学杂志，2017，20（11）：796-800.
[13]	Disse E，Graeppi-Dulac J，Joncour-Mills G，et al．Heterogeneity of pregnancy outcomes and risk of LGA neonates in Caucasian females according to IADPSG criteria for gestational diabetes mellitus[J]．Diabetes Metab，2013，39（2）：132-138.
[14]	Black MH，Sacks DA，Xiang AH，et al.Clinical outcomes of pregnancies complicated by Mildgestational diabetes mellitus differ by combinations of abnormal oral glucose tolerance testvalues[J]．Diabetes Care，2010，33（12）：2524-2530.
[16]	Stuebe AM，Landon MB，Lai Y，et al.Is there a threshold oral glucose tolerance test value for predicting adverse pregnancy outcome?[J]．Am J Perinatol，2015，32 （9）：833-838．
[17]	Metzger BE，Gabbe SG．International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia inpregnancy[J].Diabetes Care，2010，33（3）：676-682.