三酰甘油/高密度脂蛋白胆固醇比值与2型糖尿病患者合并骨质疏松的相关性

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Abstract Objective To investigate the correlation between the ratio of triglyceride (TG) to high density lipoprotein cholesterol (HDL-C) and patients with type 2 diabetes complicated with osteoporosis. Methods A total of 186 hospitalized patients with type 2 diabetes in our hospital from April 2018 to April 2019 were selected as subjects. According to the differences in bone mineral density of lumbar spine and proximal end of left femur detected by dual energy x-ray absorptiometry, the patients were divided into normal bone mass group (64 cases), osteopenia group (77 cases) and osteoporosis group(45 cases).Venous blood was collected from patients in the three groups,and fasting blood glucose(FBG),uric acid (UA), TG, total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol (LDL-C), cystatin C (CysC), and serum glycosylated hemoglobin (HbA1c) were detected. The correlation between the ratio of TG/HDL-C and bone mineral density was analyzed by One-way analysis of variance and Pearson correlation. Results The body mass index(BMI), UA, TG and TG/HDL-C of the osteoporosis group were lower than those of the osteopenia group and the normal bone mass group, and the differences were statistically significant (P＜0.05). The duration of diabetes in the osteoporosis group was longer than that in the osteopenia group and the normal bone mass group, HDL-C, LDL-C and CysC were higher than those in the osteopenia group and the normal bone mass group, and the differences were statistically significant (P＜0.05). BMI, UA, TG and TG/HDL-C in the osteopenia group were lower than those in the normal bone mass group, with statistically significant differences (P＜0.05). The duration of diabetes in the osteopenia group was longer than that in the normal bone mass group, and HDL-C, LDL-C and CysC were higher than those in the normal bone mass group,with statistically significant differences(P＜0.05).Pearson correlation analysis results showed that TG/HDL-C was positively correlated with bone mineral density of lumbar L1-4, left femoral neck, femoral trochanter, wards triangle and all femur in patients with type 2 diabetes (r=0.275, 0.281, 0.276, 0.268, 0.287, P＜0.001). Conclusion Low TG/HDL-C is related to the increased risk of type 2 diabetes complicated with osteoporosis.

Key words： Type 2 diabetes Ratio of triglyceride to high density lipoprotein cholesterol Osteoporosis

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	Articles by authors
	HE Sheng-qing
	ZHENG Xiao-bing
	WU Hong-mei

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HE Sheng-qing,ZHENG Xiao-bing,WU Hong-mei. Correlation between the ratio of triglyceride to high density lipoprotein cholesterol and patients with type 2 diabetes complicated with osteoporosis[J]. 中国当代医药, 2020, 27(16): 113-116.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I16/113

[2]	贺丽英，孙蕴，要文娟，等.2010~2016年中国老年人骨质疏松症患病率Meta 分析[J].中国骨质疏松杂志，2016，22（12）：1590-1596.
[5]	Jiang N，Xia W.Assessment of bone quality in patients with diabetes mellitus[J].Osteoporos Int，2018，29（8）：1721-1736.
[1]	Wang L，Gao P，Zhang M，et al.Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J].JAMA，2017，317（24）：2515-2523.
[3]	Valderrábano RJ，Linares MI.Diabetes mellitus and bone health：epidemiology，etiology and implications for fracture risk stratification[J].Clin Diabetes Endocrinol，2018，4（1）：9.
[4]	Chen Z，Zhao GH，Zhang YK，et al.Research on the correlation of diabetes mellitus complicated with osteoporosis with lipid metabolism，adipokines and inflammatory factors and its regression analysis[J].Eur Rev Med Pharmacol Sci，2017，21（17）：3900-3905.
[6]	Cortet B，Lucas S，Legroux -Gerot I，et al.Bone disorders associated with diabetes mellitus and its treatments[J].Joint Bone Spine，2019，86（3）：315-320.
[7]	张云，鲁平.老年2型糖尿病患者合并骨质疏松的相关因素分析[J].中华老年医学杂志，2018，37（4）：417-419.
[8]	晏丕军，欧阳芳，马红艳，等.2型糖尿病患者血清胱抑素C 与骨质疏松的相关性[J].山西医科大学学报，2016，47（1）：59-63，96.
[9]	Lee MY，Hsiao PJ，Huang JC，et al.Associations between triglyceride/high-density lipoprotein cholesterol ratio and micro-and macroangiopathies in type 2 diabetes mellitus[J].Endocr Pract，2018，24（7）：615-621.
[10]	Yang M，Rigdon J，Tsai SA.Association of triglyceride to HDL cholesterol ratio with cardiometabolic outcomes[J].J Investig Med，2019，67（3）：663-668.
[11]	Yang Y，Liu G，Zhang Y，et al.Association between bone mineral density，bone turnover markers，and serum cholesterol levels in type 2 diabetes[J].Front Endocrinol （Lausanne），2018，9：646.
[12]	Cui R，Zhou L，Li Z，et al.Assessment risk of osteoporosis in Chinese people：relationship among body mass index，serum lipid profiles，blood glucose，and bone mineral density[J].Clin Interv Aging，2016，11：887-895.
[13]	杨红英，李虹，刘璐，等.绝经后女性骨密度与维生素D和高密度脂蛋白水平相关性研究[J].中国骨质疏松杂志，2019，25（2）：193-197.
[14]	Wu Y，Xing X，Ye S，et al.Lipid levels related to osteoporosis in patients with type 2 diabetes[J].Exp Clin Endocrinol Diabetes，2019，127（7）：468-472.
[15]	Dragojevic J，Zupan J，Haring G，et al.Triglyceride metabolism in bone tissue is associated with osteoblast and osteoclast differentiation：a gene expression study[J].J Bone Miner Metab，2013，31（5）：512-519.
[16]	渠航，于杨，秦树存，等.异常修饰后高密度脂蛋白组分的改变对其功能的影响[J].生理学报，2017，69（2）：225-234.