2型糖尿病肾病与血糖波动及氧化应激水平的相关性分析

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Abstract Objective To explore the correlation between type 2 diabetic nephropathy and blood glucose fluctuation and oxidative stress. Methods A total of 90 patients with type 2 diabetes who were admitted to our hospital from January 2015 to December 2017 were selected. According to the 24-hour urine microalbumin (UAlb) determination results, they were divided into the normal UAlb group (43 cases) and the high UAlb group (47 cases). General clinical data, blood glucose, blood lipid and other biochemical indicators of patients in the 2 groups were recorded, and the levels of oxidative stress index superoxide dismutase (SOD) and malondialdehyde (MDA) were detected. The seven-stage self-monitoring of blood glucose was improved, and the standard deviation of blood glucose level (SDBG) was calculated. Results Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), systolic blood pressure, diastolic blood pressure, course of diabetes, SDBG, SOD, MDA, and UAlb of the two groups were compared, and the differences were statistically significant (P＜0.05). The results of correlation analysis showed that UAlb was positively correlated with the course of disease, SDBG and MDA in patients with type 2 diabetes (r=0.298, 0.435, 0.673, P＜0.05). There was a negative correlation between UAlb and SOD (r=-0.716, P＜0.05). SOD was negatively correlated with SDBG (r=-0.294, P＜0.05). MDA was positively correlated with SDBG (r=0.282, P＜0.05). Conclusion The course of diabetes, the fluctuation of blood glucose and the level of oxidative stress are correlated with the occurrence and development of diabetic nephropathy.

Key words： Type 2 diabetic nephropathy Blood glucose fluctuation Oxidative stress

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	FAN Ling-yan
	LU Xue-ling

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FAN Ling-yan,LU Xue-ling. Correlation analysis of type 2 diabetic nephropathy with blood glucose fluctuation and oxidative stress[J]. 中国当代医药, 2020, 27(16): 102-105.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I16/102

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