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| Application effect of Urapidil combined with Esmolol for controlled hypotension in patients with intracranial aneurysm interventional surgery |
| LOU Jian-yun WANG Hai-bin ZENG Zhao-bin LUO Jun CHEN Jin-ming YI Ren-hui |
| Department of Neurosurgery, the First Affiliated Hospital of Gannan Medical University, Jiangxi Province, Ganzhou 341000, China |
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Abstract Objective To investigate the application effect of Urapidil combined with Esmolol for controlled hypotension in patients with intracranial aneurysm interventional surgery. Methods A total of 220 patients with intracranial aneurysms admitted to our hospital from January 2017 to January 2019 were selected as the research objects, and the patients were divided into observation group (110 cases) and control group (110 cases) according to the random number table method. Patients in the observation group were given Urapidil combined with Esmolol for controlled hypotension,and patients in the control group were given Sodium Nitroprusside for controlled hypotension. The intraoperative blood pressure stability, ventilation, oxygenation scores, total amount of Isoflurane inhalation and blood pressure control were compared, and the postoperative mean arterial pressure, hemorheology, normal electrocardiogram score, normal blood pressure monitoring score and end-tidal carbon dioxide partial pressure were compared between the two groups. Results The intraoperative blood pressure stability, ventilation and oxygenation scores in the observation group were higher than those in the control group, and the total amount of Isoflurane inhalation was less than that in the control group,with statistically significant differences (P＜0.05). The postoperative mean arterial pressure, hemorheology and end-tidal carbon dioxide partial pressure in the observation group were lower than those in the control group, and the normal electrocardiogram and normal blood pressure monitoring scores were higher than those in the control group, with statistically significant differences (P＜0.05). The stability score of blood pressure in the observation group was higher than that in the control group, the fluctuation range of blood pressure was smaller than that in the control group, and the dosage of antihypertensive drugs was less than that in the control group, with statistically significant differences (P＜0.05). Conclusion Urapidil combined with Esmolol in interventional surgery for intracranial aneurysms has a good effect in controlled hypotension, and the stability of blood pressure is good, which is conducive to achieving good surgical results.
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| [1] |
陈建华，宋和平，陆瑾.国内外高血压诊断标准比较[J].中西医结合心脑血管病杂志，2014，12（5）：527-528.
|
| [2] |
刘佳梅，刘佳，蔡军，等.原发性高血压相关代谢组学的初步研究[J].中华高血压杂志，2016，24（4）：340-347.
|
| [3] |
邓婷婷，周素娴.2型糖尿病合并高血压患者血脂，血糖代谢情况及其与高血压病程的关系[J].广东医学，2014，35（5）：722-724.
|
| [4] |
殷玥琪，杨立刚，孙桂菊.高脂血症与高血压相关性及其代谢异常研究进展[J].中国老年学杂志，2014，34（5）：1414-1417.
|
| [5] |
刘淑亮，陈玉双，王荆夫.96 例脑动脉瘤CTA 和DSA 检查诊断结果的对比研究[J].医学理论与实践，2018，31（21）：3171-3173.
|
| [6] |
Brinjikji W，Morales-Valero SF，Murad MH，et al.Rescuetreatment of thromboembolic complications duringendovascular treatment of cerebral aneurysms:a meta-analysis[J].AJNR Am J Neuroradiol，2015，36（1）：121-125.
|
| [7] |
王雄伟，陈晖.瑞芬太尼复合右美托咪定在心脏手术中的麻醉效果及对患者血流动力学的影响[J].实用药物与临床，2013，16（9）：799-801.
|
| [8] |
吴萍，林梓霞，郑良杰，等.脊柱手术中血液稀释，控制性降压联合血液回收减少术中出血效果观察[J].山东医药，2014，54（30）：89-90.
|
| [9] |
梁晓东，王子亮，李天晓，等.盐酸替罗非班在颅内动脉瘤介入治疗中的应用进展[J].中华介入放射学电子杂志，2016，4（1）：44-47.
|
| [10] |
中华医学会神经外科学分会神经介入组.颅内动脉瘤血管内介入治疗中国专家共识（2013）[J].中华医学杂志，2013，93（39）：3093-3103.
|
| [11] |
冯顺华，韩超，余露，等.右美托咪定对颅内动脉瘤介入治疗患者血流动力学的影响[J].医学临床研究，2016，33（2）：223-225.
|
| [12] |
黄斌，李闯，焦晶华.颅内动脉瘤患者应用右美托咪定在麻醉诱导期的血流动力学变化研究[J].当代医学，2017，23（5）：55-56.
|
| [13] |
侯锐，吴芳，何黎升，等.高血压拔牙患者控制性降压的随机双盲临床研究[J].中国口腔颌面外科杂志，2014，12（1）：51-55.
|
| [15] |
任江，江华.鼻内镜手术应用乌拉地尔联合艾司洛尔控制性降压的可行性分析[J].当代医学，2016，22（16）：134-135.
|
| [16] |
梁爱军.大脑中动脉分叉部动脉瘤并发脑内血肿的显微手术治疗体会[J].中国实用神经疾病杂志，2013，16（23）：47-49.
|
| [17] |
王蓓蓓，廖山婴，马娟，等.不同病因急性胰腺炎的临床特点分析[J].临床肝胆病杂志，2018，34（1）：147-151.
|
| [18] |
张乐乐，方剑乔，邵晓梅，等.TEAS 复合药物全麻对控制性降压至60%基础MAP 水平时的胃动力变化影响[J].中国中西医结合杂志，2015，35（1）：98-103.
|
| [14] |
Diemunsch P，Garcia V，Lyons G，et al.Urapidil versus nicardipine in preeclamptic toxaemia：a randomised feasibility study[J].Eur J Anaesthesiol，2015，32（11）：822-823.
|
| [19] |
邵晓梅，方剑乔，周传龙，等.经皮穴位电刺激复合药物全麻行控制性降压对丘脑局部血流的影响[J].临床麻醉学杂志，2012，28（6）：599-601.
|
| [20] |
秦钟，许波，王志萍.不同剂量瑞芬太尼复合七氟醚控制性降压对神经外科手术患者脑氧代谢的影响[J].临床麻醉学杂志，2012，28（2）：118-121.
|
| [21] |
张艳玲，陈知，罗国标，等.持续微泵静注芬太尼、硝普钠及艾司洛尔治疗急性主动脉夹层的疗效观察[J].中国医药科学，2018，8（7）：76-78，101.
|
| [22] |
李华庆.高血压腹部手术患者术中乌拉地尔复合艾司洛尔控制性降压的可行性研究[J].当代医学，2018，24（6）：23-25.
|
|
|
|
