我院近四年病原菌的分布及药敏监测的对比分析

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Abstract Objective To understand the distribution of pathogenic bacteria and the change of drug-resistant bacteria in our hospital, and sort out the monitoring data of antimicrobial resistance in the past four years, so as to provide the basis for clinical rational selection of antimicrobial drugs. Methods The monitoring data of drug resistance every quarter from 2016 to 2019 in our hospital were collected, including the distribution of main pathogenic bacteria, the drug sensitivity of main Gram-negative bacteria, the detection of multiple drug-resistant bacteria, etc.The annual data of the detection were sorted out and statistically analyzed to find out the changes of bacterial drug resistance rate, included main Enterobacteriaceae bacteria, Extended-Spectrum β-Lactamases (ESBL), and the drug sensitivity of main Gram-negative bacteria. Results A total of 24 430 strains were collected in the past four years, the main Gram-positive bacteria accounted for 26.52%, the first three were Coagulase negative staphylococcus, Enterococcus and Staphylococcus aureus.The main Gram-negative bacteria accounted for 42.40%, the first three were Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia.The detection rate of ESBL produced by Klebsiella pneumoniae increased significantly.The sensitivity of Imipenem-Cilastatin increased in Pseudomonas aeruginosa significantly, with 97.75% in recent years.However, in Enterobacteriaceae bacteria producing ESBL and Acinetobacter baumannii, the sensitivity of Imipenem-Cilastatin decreased significantly.In Pseudomonas aeruginosa, the sensitivity of Imipenem-Cilastatin increased significantly. Conclusion The detection rate of drug-resistant bacteria in hospital is still increasing, especially the drug resistance of Acinetobacter baumannii can′t be ignored.It is necessary to strengthen the monitoring of bacterial drug resistance, improve the management measures of drug-resistant bacteria such as hand hygiene management, establish multi-disciplinary professional cooperative management, and promote the rational application of antibiotics.

Key words： Drug resistance of pathogenic bacteria;Carbapenems Extended-Spectrum β-Lactamases Drug sensitivity

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