儿童良性癫痫伴中央颞区棘波药物疗效不佳的影响因素分析

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Abstract Objective To analyze the clinical features and electroencephalogram (EEG) characteristics of benign epilepsy of childhood with centrotemporal spikes (BECT), and to discuss the influencing factors of poor drug response. Methods A retrospective analysis was conducted on the clinical data (including low age of onset, frequency of seizures, type of seizures, time of seizures, history of fever seizure, and family history of convulsions) and EEG characteristics (including spur/spike [spine/slow complex wave]discharge, discharge period, discharge generalization) of 101 children newly diagnosed with BECT in our hospital from January 2016 to December 2018.All subjects were routinely treated with antiepileptic drugs, and followed up for at least one year, including control of seizure, new form of seizure and evolution of EEG.The subjects were then divided into seizure free group (83 cases) and poor drug response group (18 cases) according to whether there were seizures after one year of treatment.The differences in clinical characteristics and EEG characteristics before treatment between the two groups as well as the factors influencing poor drug response were analyzed. Results There were statistically significant differences in the low age of onset, frequency of seizures, and type of seizures between the two groups (P＜0.05).There were no statistically significant differences in time of seizures, history of fever seizure, and family history of convulsions between the two groups (P＞0.05).Multivariate Logistic regression analysis showed that the frequency of seizures was the influencing factor of poor drug response (P＜0.05). Conclusion BECT generally has a good prognosis, and its drug response is related to low age of onset (＜5 years old), the frequency of seizures, and the type of seizures, among them, the frequency of seizures is an influential factor for poor drug response.

Key words： Benign epilepsy of childhood with centrotemporal spikes Clinical features Electroencephalogram Drug response

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	ZHOU Xing
	LIU Zhi-gang
	DONG Shi-wei

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ZHOU Xing,LIU Zhi-gang,DONG Shi-wei. Analysis of the influencing factors of poor drug response of benign epilepsy of childhood with centrotemporal spikes[J]. 中国当代医药, 2020, 27(15): 142-145转149.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I15/142

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