脂溶性维生素注射液联合丁二磺酸腺苷蛋氨酸治疗酒精性肝病伴肝内胆汁淤积的临床效果

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Abstract Objective To evaluate the clinical effect of Fat-Soluble Vitamin Injection combined with Adenosine Butadionate Methionine in the treatment of alcoholic liver disease with intrahepatic cholestasis. Methods Clinical data of 126 cases of alcoholic liver disease with intrahepatic cholestasis patients in our hospital during December 2016 to March 2019 were retrospectively analyzed.According to the treatment methods they were divided into control group(68 cases), observation group(58 cases).Patients in control group were treated with Adenosine Butadionate Methionine,those in study group used Fat-Soluble Vitamin Injection combined with Adenosine Butadionate Methionine treatment.Short-term efficacy, liver functionindexes (glutamic oxaloacetic transaminase [AST], alanine aminotransferase [ALT], total bilirubin [TBil], alkaline phosphatase [ALP]), coagulation indexes (prothrombin time [PT], thrombin time [TT], activated partial thromboplastin time [APTT], fibrinogen [FIB]and thromboplastin function [PT]), soluble adhesion molecule-1 (sVCAM-1) and phospholipid transporter (PLTP) were compared between two groups.During treatment period, the incidence of adverse drug reactions were recorded. Results 4 weeks after treatment, the total effective rate in study group was higher than that in control group (χ2=4.645，P=0.031); levels of AST, ALT, TBil and ALP in study group were lower than those in control group (t=15.964, 19.451, 18.656, 9.130，P＜0.05); the PT, TT and APTT in study group were shorer than those in control group, FIB was higher than that in the control group (t=3.334、5.520、4.873、6.704，P＜0.05); levels of sVCAM-1 and PLTP in the control group were lower than those in the control group (t=12.543、6.717, P＜0.05).During treatment, there was no significant difference in the total incidence of adverse drug reactions between two groups (P＞0.05). Conclusion The effect of Fat-Soluble Vitamin Injection combined with Adenosine Butadionate Methionine in patients with alcoholic liver disease and intrahepatic cholestasis is reliable.At the same time, it has good therapeutic safety.

Key words： Alcoholic liver disease Intrahepatic cholestasis Fat-Soluble Vitamin Injection Adenosine Butadionate Methionine Liver function Coagulation function

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	ZHANG Zhi-gang
	LEI Yuan-feng

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ZHANG Zhi-gang,LEI Yuan-feng. Clinical effect of Fat-Soluble Vitamin Injection combined with Adenosine Butadionate Methionine in the treatment of alcoholic liver disease with intrahepatic cholestasis[J]. 中国当代医药, 2020, 27(15): 20-23转27.

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