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Clinical effect of Azithromycin in the treatment of Mycoplasma pneumonia in children |
YAN Neng-rong1 WU Zu-cheng2 PENG Xiang-juan3 WANG Si-meng4 |
1.Department of Pediatrics,the Second People′s Hospital of Bao′an People′s Hospital (Group),Guangdong Province,Shenzhen 518108,China;
2.Quality Control Center,Shiyan People′s Hospital of Bao′an District in Shenzhen City,Guangdong Province,Shenzhen 518108,China;
3.Department of Neonatology,Shiyan People′s Hospital of Bao′an District in Shenzhen City,Guangdong Province,Shenzhen 518108,China;
4.Department of Brain,Shiyan People′s Hospital of Bao′an District in Shenzhen City,Guangdong Province,Shenzhen 518108,China |
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Abstract Objective To study the clinical effect of Azithromycin on Mycoplasma pneumonia in children.Methods A total of 100 children with mycoplasma pneumoniae from Shiyan People′s Hospital of Baoan District in Shenzhen City from February 2016 to February 2018 were selected as the study subjects.According to their admission order,they were divided into observation group (50 cases) and control group (50 cases).Patients in the observation group were treated with Azithromycin and patients in the control group were treated with Ambroxol.Treatment indicators,C-reactive protein (CRP),tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),adverse reactions and therapeutic effect were compared between the two groups.Results The temperature recovery time ([2.01±0.23]d),cough disappearance time ([10.23±1.45]d),symptom improvement time ([6.23±1.22]d) and hospital stay time ([12.22±1.82]d) of the observation group were all shorter than those of the control group ([4.66±1.23],[12.56±1.82],[15.56±1.23]d),with statistically significant differences (P<0.05).After treatment,TNF-α ([11.09±1.66]pg/ml),IL-6 ([12.01±1.24]pg/ml) and CRP([7.01±1.24]mg/L) in the observation group were all lower than those in the control group ([15.76±1.02]pg/ml,[15.99±1.04]pg/ml,and [12.77±1.98]mg/L),with statistically significant differences (P<0.05).The total incidence of adverse reactions in the observation group (2.00%) was lower than that in the control group (22.00%),and the difference was statistically significant (P<0.05).The total effective rate (96.00%) of the observation group was higher than that of the control group (72.00%),and the difference was statistically significant (P<0.05).Conclusion Azithromycin is an effective and safe treatment for Mycoplasma pneumonia in children.
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