药敏检测指导在幽门螺杆菌根除治疗中的应用效果

Abstract
Figure/Table
References (22)
Related Citation (15)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the application effect of drug sensitivity test guidance in the eradication therapy of Helicobacter pylori.Methods From January 2017 to January 2019,60 patients with Helicobacter pylori infection diagnosed and treated in Kuichong People′s Hospital of Dapeng New District of Shenzhen City were selected as the research objects,according to the method of random number table,the selected patients were divided into the observation group and the control group,30 cases in each group.Both groups were treated with quadruple therapy.The patients in the control group were treated with Bismuth Potassium Citrate Capsules,Omeprazole Enteric Coated Capsules,Amoxicillin Capsules and Clarithromycin according to the doctor′ clinical experience.Patients in the observation group were treated with two antibiotics combined with Omeprazole Enteric Coated Capsules and Bismuth Potassium Citrate Capsules according to the results of drug sensitivity test.The drug sensitivity test results of the observation group were recorded,and the eradication rate and the total incidence rate of adverse reaction of Helicobacter pylori in the two groups after treatment were compared,the therapeutic effect of the two groups was observed.Results Drug sensitivity test results showed that the drug resistances rates of Amoxicillin,Clarithromycin,Metronidazole,Ciprofloxacin and Rifampin were 0.00%,23.33%,80.00%,23.33% and 3.33%,respectively.The eradication rate of Helicobacter pylori in the observation group was 93.33%,which was higher than 66.67% in the control group,the difference was statistically significant (P＜0.05).The total effective rate of the observation group was 96.67%,which was higher than 70.00% of the control group,the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The application and effect of drug sensitivity test guidance in the eradication therapy of Helicobacter pylori is significant,which can improve the eradication rate of Helicobacter pylori,and it is worthy of clinical promotion and application.

Key words： Drug sensitivity test Helicobacter pylori Eradication therapy Application effect

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Shao-wen
	LI Kai-xue
	LIU Ai-jun

Cite this article:

CHEN Shao-wen,LI Kai-xue,LIU Ai-jun. Application effect of drug sensitivity test guidance in eradication therapy of Helicobacter pylori[J]. 中国当代医药, 2020, 27(14): 40-42转64.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I14/40

[1]	周璐祎.幽门螺杆菌感染与炎症性肠病关系的临床研究[D].新乡：新乡医学院，2017.
[2]	李霞.布拉酵母菌散荆花胃康胶丸联合标准四联疗法治疗幽门螺杆菌相关性胃炎及十二指肠溃疡疗效观察[J].中国药物与临床，2018，18（4）：600-601.
[3]	刘文忠.如何看待根除幽门螺杆菌的负面影响[J].中华消化杂志，2017，37（3）：164-166.
[4]	周丽雅，肖士渝.幽门螺杆菌与胃癌的研究进展[J].临床内科杂志，2018，35（12）：797-799.
[5]	涂宏飞，费素娟.幽门螺杆菌CagA及VacA致病机制的研究进展[J].中国中西医结合消化杂志，2019，27（5）：81-84.
[6]	狄艳青，郭宏华.抗菌肽根除幽门螺杆菌研究进展[J].中国实用内科杂志，2017，37（12）：1115-1118.
[7]	耿熙炆.转运蛋白HP0497参与调控幽门螺杆菌适应克拉霉素压力[D].济南：山东大学，2017.
[8]	张华宝.不同时间段抗幽门螺杆菌治疗消化性溃疡的临床疗效[J].世界临床医学，2017，11（2）：118，120.
[9]	赵亚莉.中西医结合治疗消化性溃疡效果观察[J].临床医学研究与实践，2017，2（24）：130-131.
[10]	周欢.幽门螺杆菌外膜囊泡诱导AD样tau病变[D].武汉：华中科技大学，2018.
[11]	李滨.幽门螺杆菌表位特异性CD4+T 细胞免疫保护机制及CD8+T 细胞应答特征研究[D].重庆：第三军医大学，2017.
[12]	彭超，谢川，吕农华.幽门螺杆菌在胃内定植的相关影响因素[J].中国微生态学杂志，2017，29（3）：363-366.
[13]	马田.合并幽门螺杆菌感染的非萎缩性胃炎、萎缩伴肠上皮化生和胃癌患者的胃内菌群[D].济南：山东大学，2017.
[14]	罗宜辉，刘代华.阿莫西林不同给药方案对根除幽门螺杆菌疗效的影响[J].中国医药导报，2019，16（19）：148-151.
[15]	郭长城，熊妍，吴芳草，等.胃内尿素酶阳性细菌对幽门螺杆菌感染诊断的影响[J].中国病原生物学杂志，2018，13（2）：127-130.
[16]	张晓瑜.幽门螺杆菌毒力因子CagA和尿素酶代谢物NH4＋对AGS 细胞中黏蛋白表达的影响[D].郑州：河南中医药大学，2018.
[17]	刘鑫，石岩岩，丁士刚.幽门螺杆菌感染和慢性胃炎的关系[J].临床荟萃，2019，34（5）：389-393.
[18]	朱春平，赵建业，钱维，等.不同Hp感染状态下血清胃泌素-17对胃窦萎缩的诊断价值[J].胃肠病学，2017，22（5）：282-286.
[19]	王亮亮，高峰.益生菌对幽门螺杆菌感染的治疗作用[J].新疆医学，2017，47（9）：966-969.
[20]	黄秋月，于靖，叶晖，等.基于黏附机制探讨HP感染中医预防特色[J].北京中医药，2018，37（10）：35-38.
[21]	陈超英，张梦，王霄腾，等.序贯疗法根除幽门螺杆菌疗效的meta分析[J].胃肠病学，2017，22（3）：172-177.
[22]	汪胜林，王建宁，翟启智，等.培菲康联合三联疗法根除幽门螺杆菌临床疗效观察[J].吉林医学，2018，7（1）：116-118.