不同剂量等渗及低渗造影剂在脑血管病介入诊断中肾毒性的比较

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Abstract ObjectiveTo contrast the renal toxicity of different doses and different types of contrast agents in the diagnosis of cerebrovascular disease intervention.Methods300 cases with cerebrovascular disease in the Department of Neurosurgery of the First Hospital Affiliated to Nanchang University from July 2015 to May 2017 were selected as objects,and all patients were randomly divided into isotonic contrast agents group and hypotonic contrast agents group,and there were 150 cases in each group.According to the imaging findings and their families will,patients without surgery or intends to do surgical operation were divided into small dose of contrast agents group with no longer injection of contrast agents.Patients given immediately endovascular treatment of cerebrovascular disease were divided into large dose of contrast agents group injected with the same type contrast agents.42 cases were divided into small dose of isotonic contrast medium group,108 cases were divided into large dose of isotonic contrast medium group,51 cases were divided into small dose of hypotonic contrast agents group,99 cases were divided into large dose of hypotonic contrast agents group.Serum cystatin C(CysC),serum creatinine(SCr)before,and at 24 h,48 h,72 h after operation among various groups were compared.ResultsThe level of CysC and SCr in all groups were higher than before the operation (P＜0.05).The incidence of contrast nephropathy (CIN),CysC and SCr level in small dose group were lower than those of large dose group with the same type contrast agents(P＜0.05).CysC level of large dose of isotonic contrast medium group was significantly reduced compared with large dose of hypotonic contrast agents group(P＜0.05),but there was no statistically significant difference in the incidence of CIN and SCr level(P＞0.05).ConclusionThe renal toxicity of the contrast medium is related to the dosage of the drug.Isotonic contrast agents is safer than low-osmolar contrast agents in large dosage.

Key words： Cerebrovascular disease Interventional diagnosis and treatment Contrast-induced nephropathy Cystatin C Serum creatinine

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	ZHOU Yang
	ZHOU Xiao-bing
	YIN Jin-feng

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ZHOU Yang,ZHOU Xiao-bing,YIN Jin-feng. Renal toxicity comparison of different doses of isotonic and hypotonic contrast agents in the interventional diagnosis of cerebrovascular disease[J]. 中国当代医药, 2017, 24(30): 4-7.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I30/4

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