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| Clinical effect of preemptive analgesia with Dizocine in the treatment of elevated blood pressure variability in very elderly patients with hypertension |
| JIN Xin-qiang1 YUAN He-mei1 YU Lian-fang2 YU Ling-lin1 QIAN Kun-lian1 HUANG Li-hua1 HAN Jian-ping3 WU Min4 |
1. Department of Anesthesiology, People′s Hospital of Deqing County, Zhejiang Province, Deqing 313216, China;
2. Department of Cardiology,People′s Hospital of Deqing County,Zhejiang Province,Deqing 313216,China;
3.Department of Surgery and Orthopaedics, People′s Hospital of Deqing County, Zhejiang Province, Deqing 313216, China;
4. Department of Laboratory, People′s Hospital of Deqing County, Zhejiang Province, Deqing 313216, China |
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Abstract Objective To observe the clinical effect of preemptive analgesia with Dizocine in the treatment of elevated blood pressure variability (BPV) in very elderly patients with hypertension. Methods From July 2017 to February 2019,60 very elderly patients with hypertension underwent unilateral femoral surgery under general anesthesia were selected as the study subjects. They were divided into two groups by random number table method: Dizocine group (group D)and control group (group C), with 30 cases in each group. Dizocine 0.15 mg/kg was used in group D and saline of equal volume was used in control group. Intravenous injection was carried out 15 minutes before induction of anesthesia. The mean systolic blood pressure (MSBP), mean diastolic blood pressure (MDBP), systolic blood pressure coefficient of variability (SBPCV) and diastolic blood pressure coefficient of variability (DBPCV) at 24 hours after operation were compared between the two groups. The concentration of cortisol (Cor), epinephrine (E) and norepinephrine (NE) at preoperative, postoperative and 24 hours after operation were compared between the two groups. Ramsay sedation score (RSS),visual analogue scale (VAS) score and the occurrence of adverse reactions were compared between the two groups. Results The MSBP, MDBP, SBPCV and DBPCV in group D were lower than those in group C 24 h after surgery,with statistically significant differences (P ＜0.05). The Cor, E and NE concentrations in group D were lowerthan those in group C at the end of operation, with statistically significant differences (P＜0.05). There was no significant difference in RSS score between the two groups (P＞0.05). VAS score in group D was lower than that in group C, and the effective rate of analgesia was higher than that in group C, with statistically significant differences (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Preemptive analgesia with 0.15 mg/kg of Dizocine before induction can reduce the level of BPV in very elderly patients with hypertension without increasing the incidence of adverse reactions, which is worthy of clinical recommendation.
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