脓毒症患者并发毛细血管渗漏综合征的危险因素分析

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (32 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the risk factors for the occurrence of capillary leak syndrome in patients with sepsis.Methods A total of 100 patients with sepsis treated in our hospital from October 2017 to September 2018 were selected as the subjects.According to whether suffering from the complication of capillary leak syndrome, the patients were divided into the leakage group (n=13, with the complication of capillary leak syndrome) and non-leakage group (n=87,without complication of capillary leak syndrome).The clinical data of the two groups were compared and analyzed.The risk factors of capillary leak syndrome in patients with sepsis were also analyzed.Results For patients in the leakage group, the levels of procalcitonin (PCT), C-reactive protein (CRP), angiopoietin-2 (Ang2), angiopoietin receptor 2 antibody (Tie2), fasting blood glucose and lactic acid, and the score of sepsis-related organ failure assessment (SOFA) were higher than those of the non-leakage group, and the angiopoietin-1 (Ang1) level was lower than that of the non-leakage group, the incidence of coagulation disorders and multiple organ dysfunction syndrome (MODS) involved with three organs or more was higher than that of non-leakage group, and the state of sepsis was more serious than that of the non-leakage group, the differences were statistically significant (P＜0.05).Logistic multivariate analysis showed that the level of Ang1 decreased (β=0.363, OR=1.247, 95%CI [1.121, 1.697]), the levels of Ang2 (β=0.964, OR=1.356, 95%CI[1.135, 1.896]) and Tie2 receptor increased [β=0.891, OR=1.289, 95%CI [1.127, 1.731]), high lactic acid level (β=0.569, OR=1.256, 95%CI [1.112, 1.863]), high SOFA score (β=0.921, OR=1.264, 95%CI [1.125, 1.896]), the state of sepsis was severe [β=0.634, OR=1.446, 95%CI [1.141,1.934]), the organs involved by MODS was three or more(β=0.697, OR=1.446, 95%CI [1.256, 1.943]) were risk factors for the occurrence of capillary leak syndrome in patients with sepsis (P＜0.05).Conclusion The decreased Ang1 level, and elevated Ang2 and Tie2 receptor levels, high level of serum lactate, high score of SOFA, severe sepsis, three or more organs involved by MODS are all the risk factor for the occurrence of capillary leak syndrome in patients with sepsis.

Key words： Sepsis Capillary leak syndrome Risk factors Lactic acid Angiopoietin-1 Angiopoietin-2 Angiopoietin receptor 2 antibody

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YANG Wen-tao
	LIN Leng
	CHEN Ning

Cite this article:

YANG Wen-tao,LIN Leng,CHEN Ning. Analysis of risk factors for the occurrence of capillary leak syndrome in patients with sepsis[J]. 中国当代医药, 2020, 27(8): 26-28转36.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I8/26

[4]	薄禄龙，卞金俊，邓小明，等.2016年脓毒症最新定义与诊断标准：回归本质重新出发[J].中华麻醉学杂志，2016，36（3）：259-262.
[5]	陈晓燕，李元海，汪正光，等.中文版的简化SOFA评分与qSOFA评分在脓毒症患者筛查中的价值比较研究[J].中国急救医学，2019，39（6）：555-558.
[6]	方成志，彭凯伟.新生儿毛细血管渗漏综合征的实践[J].中华实用儿科临床杂志，2019，34（14）：1041-1043.
[7]	盛丽娟，赵海燕，丁悦，等.危重症新生儿毛细血管渗漏综合征的临床流行病学调查[J].中国小儿急救医学，2017，24（1）：65-68.
[8]	盛丽娟，黄为民.新生儿毛细血管渗漏综合征的早期预测与药物治疗[J].中国儿童保健杂志，2017，25（2）：158-160.
[9]	陈源美，张琪.毛细血管渗漏综合征发病机制的研究进展[J].中国小儿急救医学，2019，26（6）：461-465.
[10]	赵倩，谢月群，张涛，等.降钙素原对脓毒症患者病情及预后的临床价值[J].中华急诊医学杂志，2016，25（7）：937-943.
[11]	张越新，张玲，郭贤庆，等.PCT CRP 血乳酸APACHE ⅡSOFA评分在脓毒症患者疾病严重程度及预后评估中的价值研究[J].中国急救医学，2017，37（12）：1109-1114.
[12]	查君敬，方长太，白兆青，等.白细胞介素35、降钙素原及SOFA评分对脓毒症病情严重程度及预后的评判价值[J].重庆医学，2019，48（9）：1535-1538.
[13]	陈茜茜，陈芳.脓毒症并发毛细血管渗漏综合征的危险因素分析[J].中国全科医学，2016，19（36）：4504-4508.
[1]	梅华鲜，李永胜，陈正平，等.毛细血管渗漏指数在脓毒症并ARDS 早期诊断中的应用[J].新医学，2016，47（10）：681-685.
[2]	马焕先，史宪杰，粱雨荣，等.脓毒症合并全身性毛细血管渗漏综合征的诊疗分析[J].中华外科杂志，2017，55（9）：702-707.
[3]	张海洋，乔丽娜.儿童脓毒症并发毛细血管渗漏综合征50例临床特点分析[J].中国现代药物应用，2019，13（4）：45-46.
[14]	吉春玲，周厚荣，杨秀林，等.促血管生成素-2 在脓毒症合并ARDS 患者中的作用[J].中国中西医结合急救杂志，2018，25（4）：342-345.
[15]	张艺森，徐晓涵，孙炳伟，等.脓毒症时血管内皮细胞与血管平滑肌细胞相互作用的研究进展[J].中华危重病急救医学，2016，23（2）：180-183.