阿托伐他汀联合阿仑膦酸钠治疗骨质疏松症的效果

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Abstract Objective To investigate the effect of Atorvastatin combined with Alendronate in the treatment of osteoporosis. Methods Eighty patients with osteoporosis admitted to our hospital from February 2017 to June 2018 were selected as the research objects, and they were divided into the control group (40 cases) and the study group (40 cases)according to the random number table method. Patients in control group were treated with Alendronate Tablets alone,while patients in the study group received Atorvastatin combined with Alendronate. The clinical efficacy, bone mineral density at different parts, different biochemistry indexes (alkaline phosphatase [ALP], calcium [Ca], bone gla protein[BGP], and human 25-hydroxyvitamin D [25(OH)D]) before and after treatment were compared between the two groups.The occurrence of adverse reactions between the two groups was recorded. Results The total effective rate of treatment in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Before treatment, there were no significant differences in the bone densities of the lumbar spine, femur, femoral neck,and femoral trochanter between the two groups (P＞0.05). After treatment, the bone densities of the lumbar spine, femur,femoral neck, and femoral trochanter in the two groups were higher than those before treatment, and the differences were statistically significant (P ＜0.05). The bone densities of the lumbar spine, femur, femoral neck, and femoral trochanter in the study group after treatment were higher than those in the control group, and the differences were statistically significant (P＜0.05). Before treatment, there were no significant differences in the levels of ALP, Ca, BGP and 25(OH)D between the two groups (P＞0.05). After treatment, the levels of ALP, Ca, BGP and 25(OH)D in the two groups were higher than those before treatment, and the differences were statistically significant (P＜0.05). The levels of ALP,Ca, BGP and 25(OH)D in the study group after treatment were higher than those in the control group, and the differences were statistically significant (P＜0.05). The total occurrence rate of adverse reactions of the study group was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The use of Atorvastatin combined with Alendronate in the treatment of osteoporosis has an ideal clinical effect, which can effectively alleviate the clinical symptoms of patients, with high safety at the same time, and greatly reduce the occurrence of adverse reactions, which is worthy of further promotion and application in the clinic.

Key words： Atorvastatin Alendronate Osteoporosis Bone mineral density

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