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| Effect of Ginkgolide Injection on platelet activation in patients with acute cerebral infarction |
| WU Qiong1 LIN Shao-hua2 FU Ying3 |
1.Department of Clinical Laboratory,the Second Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330000,China;
2.Department of Clinical Laboratory,People′s Hospital of Anfu County,Jiangxi Province,Anfu 343200,China;
3.Department of Traditional Chinese Medicine,the Second Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330000,China |
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Abstract Objective To investigate the effect of Ginkgolide Injection on platelet activation in patients with acute cerebral infarction (ACI).Methods A total of 112 patients with ACI treated in the Second Affiliated Hospital of Nanchang University from January 2016 to January 2018 were selected as the study subjects for retrospictive analysis.According to the different treatment methods,they were divided into the control group and the treatment group,56 cases in each group.The control group was treated with Aspirin and the treatment group was treated with Ginkgolide Injection.The levels of platelet membrane glycoprotein (PAC-1) and cluster of differentiation 62 platelet (CD62P) were compared between the two groups before and after treatment.The main adverse cardiovascular and cerebrovascular events in the two groups were analyzed.Results The total effective rate of the treatment group was 96.43%,which was higher than that of the control group (80.36%),the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in PAC-1 and CD62P levels between the two groups (P＞0.05); after treatment,the levels of PAC-1 and CD62P in the two groups were lower than those before treatment,and the levels of PAC-1 and CD62P in the treatment group were lower than those in the control group,the differences were statistically significant (P＜0.05).The total incidence of major adverse cardiovascular events in the treatment group was 3.57%,which was lower than that in the control group (14.29%),the difference was statistically significant (P＜0.05).Conclusion Ginkgolides Injection can significantly improve the clinical efficacy of ACI patients,improve platelet activation,effectively prevent thrombosis and reduce the major adverse cardiovascular events.
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| [1] |
黄攀，何晓英.D-二聚体、P 选择素联合检测对急性脑梗死病情及预后判断的价值[J].中国老年学杂志，2018，38（24）：5909-5911.
|
| [2] |
廖金明，余梦黎，秦莎莎，等.羟基红花黄色素A、芍药苷单用及联合对脑缺血再灌注损伤大鼠脑组织NF-κB 及炎症因子的影响[J].中药药理与临床，2018，34（3）：51-55.
|
| [3] |
陈聪，苏庆杰，吴海荣，等.丁苯酞注射液联合依达拉奉注射液治疗急性脑梗死的临床研究[J].中国临床药理学杂志，2018，34（4）：395-398.
|
| [4] |
崔跃，余榕捷，彭星荷，等.启动子荧光素酶报告系统检测低浓度过氧化氢激活神经肽PACAP 特异受体PAC1-R启动子的作用[J].中国生物化学与分子生物学报，2016，32（9）：1020-1026.
|
| [5] |
刘蕾，许婉华，周丽霞，等.血小板生成素水平在急性炎症状态的变化及其意义探讨[J].中国实验血液学杂志，2017，25（3）：860-865.
|
| [6] |
第四届全国第四次脑血管病学术会议.各类脑血管疾病诊断要点[J].中华神经科杂志，1996，29（6）：379-380.
|
| [7] |
郑树旺.脑梗死患者血清白细胞介素水平及血小板活化指标变化[J].中国老年学杂志，2016，36（13）：3312-3313.
|
| [8] |
梁金霞，邱志维，孔令恩，等.全血连续计数法在脑梗死抗血小板治疗患者血小板聚集率检测中的应用[J].山东医药，2016，56（20）：95-96.
|
| [9] |
宋君，朴哲，王利平.抗血小板聚集药物在卒中防治中的应用进展[J].中国脑血管病杂志，2018，15（12）：666-672.
|
| [10] |
丁忠仁.抗血小板药：现状、挑战及趋势[J].中山大学学报（医学版），2018，39（4）：481-492.
|
| [11] |
江家华，邓庆华，高于英.银杏内酯B 对急性心肌梗死患者血运重建后心室壁运动的影响[J].中成药，2018，40（2）：294-299.
|
| [12] |
周纯，王鹏.注射用尤瑞克林联合双抗血小板治疗早期急性脑梗死的临床疗效观察[J].南京医科大学学报（自然科学版），2016，36（4）：495-497.
|
| [13] |
刘秀萍，邓方.银杏内酯和白果内酯对大鼠脑缺血再灌注损伤后VEGF 的表达的影响[J].中风与神经疾病杂志，2015，32（2）：108-111.
|
| [14] |
陆丽丽，刘丹，庞春燕，等.急性脑梗死患者体内血小板CD62P 和sTLT-1 的表达水平[J].中风与神经疾病杂志，2017，34（2）：105-107.
|
| [15] |
付璐，王朝辉.CD62P 在诊断急性脑梗死疾病中的作用[J].首都医科大学学报，2015，36（5）：714-717.
|
|
|
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