糖类抗原125联合人附睾分泌蛋白4在卵巢癌患者预后评估中的作用

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Abstract [Abstract]Objective To explore the role of carbohydrate antigen 125 (CA125)combined with human epididymal secretory protein 4(HE4)in the prognosis of patients with ovarian cancer.Methods A total of 256 patients who were diagnosed as ovarian cancer by pathology from January 2010 to May 2014 were selected and followed up for four years.The general data of the patients were analyzed,and univariate and multivariate Cox were used to analyze the prognostic factors such as age,family history,menopausal status,body mass index,treatment methods,lesion diameter,degree of differentiation,staging,pathological type,degree of myometrial invasion,HE4 level and CA125 level.Results The single-factor Cox regression showed that the treatment methods,lesion diameter,degree of differentiation,staging,pathological type,degree of myometrial invasion,HE4 and CA125 had significant effects on the prognosis of the disease,and the differences were statistically significant(P＜0.05).Further,multivariate Cox regression showed that lesion diameter,degree of differentiation (G1and G2),pathological type (serous and mucinous),staging,degree of myometrial invasion,HE4 and CA125 were independent prognostic factors.Conclusion CA125 and HE4 are independent risk factors affecting the prognosis of patients with nodular ovarian cancer.They can help to screen patients with poor prognosis.

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Ovarian neoplasms Prognosis Carbohydrate antigen 125 Human epididymis secretory protein 4

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YANG Nan. Role of carbohydrate antigen 125 combined with human epididymal secretory protein 4 in the prognosis of patients with ovarian cancer[J]. 中国当代医药, 2019, 26(7): 159-161.

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