补肾壮骨方加减治疗强直性脊柱炎的临床效果

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Abstract [Abstract]Objective To explore the clinical effect of addition and subtraction of Bushen Zhuanggu Recipe in the treatment of ankylosing spondylitis(AS).Methods A total of 50 patients with AS admitted to our hospital from April 22,2016 to April 22,2018 were selected as study objects and they were divided into the control group(n=25)and observation group (n=25)according to the odd/even number group model.In the observation group,addition and subtraction of Bushen Zhuanggu Recipe was used,while in the control group,Sulfasalazine Tablets was used.The total effective rate,spinal activity degree,thoracic range of motion,finger-to-ground distance,occipital-wall distance,morning stiffness time,lumbar-back pain score,erythrocyte sedimentation rate,serum C-reactive protein and the total incidence of adverse reactions were compared between the two groups.Results There was no significant difference in spinal activity,thoracic activity,finger-to-ground distance,occipital wall distance,morning stiffness time,lumbar back pain score,erythrocyte sedimentation rate and serum C-reactive protein before treatment between the two groups(P>0.05).The total effective rate of the observation group(96.00%)was higher than that of the control group(72.00%)(P<0.05).After treatment,the spinal activity degree was(45.85±3.61)°,thoracic range of motion was(3.69±1.47)cm in the observation group,which were higher than those of the control group for(35.68±2.66)°,(2.86±1.33)cm(P＜0.05),finger-to-ground distance was(6.11±1.19)cm,occipital wall distance was(0.33±0.15)cm in the observation group,which were lower than those of the control group for(8.95±1.43),(1.54±0.38)cm(P＜0.05),morning stiffness time was(30.15±3.19)min in the observation group,which were shorter than that of the control group for(35.96±3.55)min(P<0.05),lumbar back pain score was(0.32±0.18)points,erythrocyte sedimentation rate was(14.18±1.28)mm/h,serum C-reactive protein was(4.12±0.46)mg/L in the observation group,which was lower than those of the control group for (1.32±1.55)points,(18.39±2.41)mm/h,(5.11±0.39)mg/L (P<0.05).The total incidence of adverse reactions in the observation group was 28.00%,which was lower than that in the control group(4.00%)(P<0.05).Conclusion The effect of addition and subtraction of Bushen Zhuanggu Recipe in the treatment of ankylosing spondylitis is remarkable.

Key words： Addition and subtraction of Bushen Zhuanggu Recipe Ankylosing spondylitis Effect Evaluation

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