血清糖类抗原125、人附睾上皮分泌蛋白4和卵巢癌风险预测指数联合检测在卵巢癌早期诊断中的临床价值

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Abstract Objective To explore the clinical value of serum carbohydrate antigen 125(CA125),human epididymal secretion protein 4 (HE4)and ovarian cancer risk prediction index (ROMA)in the early diagnosis of ovarian cancer.Methods A total of 50 cases of ovarian cancer,50 cases of benign ovarian lesions and 50 cases of healthy physical examination were selected as study objects from February 2017 to July 2018 in our hospital.Serum HE4 and CA125 in the 3 groups were tested by electrochemical luminescence method and their ROMA were calculated for dynamic comparison.The clinical value of single and combined detection in early diagnosis of ovarian cancer was evaluated.Results HE4 and CA125 and ROMA in ovarian cancer group were significantly higher than those in benign ovarian tumor group and healthy control group,and the differences were statistically significant(P＜0.05).The differences of HE4,CA125 and ROMA between the benign ovarian tumor group and the healthy control group were not statistically significant(P＞0.05).Combined detection of HE4,CA125 and ROMA indec had a significant advantage in diagnosing ovarian cancer.Conclusion Combined detection of HE4 and CA125 and ROMA index has important clinical value in early diagnosis of ovary.

Key words： Ovarian cancer Carbohydrate antigen 125 Human epididymal epithelial secretion protein 4 Ovarian cancer risk prediction index

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