氟比洛芬酯超前镇痛联合喷他佐辛术后镇痛在腹腔镜肾癌根治术中的应用效果

Abstract
Figure/Table
References (21)
Related Citation (15)

Download: PDF (0 KB) HTML (43 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the application effect of preemptive analgesia with Flurbiprofen Axetil and postoperative analgesia with Pentazocine for laparoscopic radical nephrectomy.Methods A total of 40 patients with laparoscopic radical nephrectomy from January 2014 to December 2017 were selected and randomly divided into the observation group and the control group,20 patients in each group.Patients in the observation group were given Flurbiprofen Axetil with 50 mg half an hour before the start and the end of the surgery,while patients in the control group were given the same volume of physiological saline.All patients were treated with intravenous controlled analgesia pump 10 minutes before the end of the operation.Patients in the observation group were treated with Sufentanil with 150 μg+Pentazocine with 60 mg+Tropisetron with 5 mg,while patients in the control group were treated with Sufentanil with 200 μg+Tropisetron with 5 mg.The mean arterial pressure(MAP)and heart rate(HR)were observed before anesthetization(T0)and at the time of operation starting(T1),operation ending(T2)and extubation(T3)in the two groups.The levels of interleukin-6 (IL-6)and tumor necrosis factor-α (TNF-α)were detected before anesthetization and at the time of 2,12,24 h after operation in the two groups.The VAS scores and BCS scores were recorded at the time of 2,12,24 h after operation in the two groups.The press times of PCIA and the incidence rate of adverse reactions were observed in the two groups.Results At T1,T2and T3,the values of MAP and HR in the observation group were significantly lower than those in the control group(P＜0.05).At the 12 h and 24 h after operation,the level of IL-6 and TNF-α in the observation group were significantly lower than those in the control group(P＜0.05).The VAS scores in the observation group were significantly higher than those in the control group(P＜0.05)at the same time point,while the BCS scores in the observation group were significantly lower than those in the control group(P＜0.05)at the same time point.The press times of PCIA in the observation group were significantly lower than those in the control group(P＜0.05),and the incidence of postoperative nausea in the observation group was significantly lower than those in the control group,with significant difference (P＜0.05).Conclusion The analgesic effect of preemptive analgesia with Flurbiprofen Axetil and postoperative analgesia with Pentazocine for laparoscopic radical nephrectomy is definite,which can effectively reduce the stress response and adverse reactions.

Key words： Flurbiprofen Axetil Preemptive analgesia Pentazocine Postoperative analgesia Laparoscopic radical nephrectomy

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I3/74

[1]	顾红星，何中寅，袁晓灵，等.腹腔镜下肾癌根治术与肾部分切除术的临床疗效分析[J].江苏医药，2014，40（17）：2063-2065.
[2]	程伟，刘修恒，陈明，等.腹腔镜与开放肾癌根治术对机体应激反应影响的比较[J].微创泌尿外科杂志，2016，5（2）：77-79.
[3]	Ben-David B.Anaesthesia in cancer surgery：can it affect cancer survival?[J].Curr Clin Pharmacol，2016，11（1）：4-20.
[4]	Benyamin R，Trescot AM，Datta S，et al.Opioid complication and side effects[J].Pain Physician，2008，11（Suppl 2）：S105-S120.
[5]	Chapman CR，Lipschitz DL，Angst MS，et al.Opioid pharmacotherapy for chronic non-cancer pain in the United States：a research guideline for developing an evidence-base[J].J Pain，2010，11（9）：807-829.
[6]	Sittl R，Imieh D，Lang PM.Update on preemptive analgesia：options and limits of preoperative pain therapy[J].Anaesthesist，2013，62（10）：789-796.
[7]	Yi P，Pryzbylkowski P.Opioid induced hyperalgesia[J].Pain Med，2015，16（Suppl 1）：S32-S36.
[9]	中华医学会麻醉学分会.促进术后康复的麻醉管理专家共识[J].中华麻醉学杂志，2015，35（2）：141-148.
[14]	王迎虎.氟比洛芬酯的药理及临床应用进展[J].天津药学，2018，30（2）：58-60.
[15]	沈莉莉，李传忠，阮春徽，等.氟比洛芬酯复合地佐辛超前镇痛对老年腹腔镜手术患者外周血T淋巴细胞亚群及炎症因子水平的影响[J].医学临床研究，2018，35（3）：539-541.
[8]	Rosero EB，Joshi GP.Preemptive，preventive，multimodal analgesia：what do they really mean[J].Plast Reconstr Surg，2014，134（4S-2）：85S-93S.
[10]	Krall JA，Reinhardt F，Mercury OA，et al.The systemic response to surgery triggers the outgrowth of distant immunecontrolled tumors in mouse models of dormancy[J].Sci Transl Med，2018，10（436）：3464.
[11]	Forget P，Machiels JP，Coulie PG，et al.Neutrophil：lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast，lung，and kidney cancer surgery[J].Ann Surg Oncol，2013，20（Suppl 3）：S650-S660.
[12]	Choi JE，Villarreal J，Lasala J，et al.Perioperative neutrophil：lymphocyte ratio and postoperative nsaid use as predictors of survival after lung cancer surgery：a retrospective study[J].Cancer Med，2015，4（6）：825-833.
[13]	Forget P，Bentin C，Machiels JP，et al.Intraoperative use of ketorolac or diclofenac is associated with improved diseasefree survival and overall survival in conservative breast cancer surgery[J].Br J Anaesth，2014，113（Suppl 1）：i82-i87.
[16]	张建华，黄旭，梁健群，等.右美托咪啶复合氟比洛芬酯对腹腔镜结直肠癌根治术患者血流动力学及苏醒期应激反应的影响[J].中国医药导报，2017，14（31）：64-67.
[17]	苏喆，张光明.术前输注氟比洛芬酯对肺癌根治术患者围术期免疫功能及血清β-EP、HMGB1水平的影响[J].实用药物与临床，2017，20（3）：268-271.
[18]	魏湘华，谭晓红，王志仪，等.乌斯他丁联合氟比洛芬酯在结肠癌手术患者快速康复中的应用[J].分子影像学杂志，2018，41（1）：89-92.
[19]	Aguado D，Abreu M，Benito J，et al.Effects of naloxone on opioid-induced hyperalgesia and tolerance to reminfentanil under sevoflurane anesthesia in rats[J].Anesthesiology，2013，118（5）：1160-1169.
[20]	韦静，彭东苓.喷他佐辛用于胸部术后镇痛的疗效观察[J].健康前沿，2018，27（7）：165.
[21]	牛静波.喷他佐辛复合舒芬太尼、昂丹司琼术后镇痛泵与曲马多复合昂丹司琼术后镇痛泵的临床比较[J].中国实用医药，2018，13（2）：98-99.