N-乙酰半胱氨酸联合小剂量阿奇霉素治疗慢性阻塞性肺疾病稳定期气道黏液高分泌的效果

Abstract
Figure/Table
References (15)
Related Citation (1)

Download: PDF (0 KB) HTML (38 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of N-acetylcysteine combined with low-dose Azithromycin on airway mucus hypersecretion in stable phase of chronic obstructive pulmonary disease (COPD).Methods Eighty-four patients with stable COPD treated in our hospital from January 2016 to October 2017 were selected as observation objects,they were divided into control group and intervention group according to random number table method,with 42 cases in each group.The control group received routine treatment,and the intervention group received N-acetylcysteine and Azithromycin on the basis of the control group,after 6 months of continuous treatment,the lung function,activity endurance and serum inflammatory factors were compared between the two groups.Results There was no significant difference between the two groups in the first second forced expiratory volume(FEV1),forced vital capacity(FVC)and FEV1/FVC (P＞0.05);After treatment,the 6-minute walking distance (6-MWD)of intervention group was longer than that of control group,the differences were statistically significant(P＜0.05).The levels of serum inflammatory factors,neutrophil elastase(NE),interleukin-8(IL-8)and interleukin-10(IL-10)in the two groups after treatment were lower than those before treatment,the differences were statistically significant(P＜0.05).After treatment,the levels of serum inflammatory factors NE,IL-8 and IL-10 in intervention group were lower than those in control group,the differences were statistically significant (P＜0.05).Conclusion N-acetylcysteine combined with low-dose Azithromycin in the treatment of stable COPD effect is significant,can improve activity endurance,reduce inflammation,reduce airway mucus secretion,delay the decline of pulmonary function,worthy of clinical promotion.

Key words： N-Acetylcysteine Low dose Azithromycin Stable phase of chronic obstructive pulmonary disease Airway mucus hypersecretion

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Fa-gen
	CHEN Xian-xiang

Cite this article:

LI Fa-gen,CHEN Xian-xiang. Effect of N-Acetylcysteine combined with low-dose of Azithromycin on airway mucus hypersecretion in stable phase of chronic obstructive pulmonary disease[J]. 中国当代医药, 2018, 25(30): 104-106.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I30/104

[1]	郭炳鹏，周露茜，关力理，等.慢性阻塞性肺疾病呼吸康复与炎症反应及氧化应激的研究进展[J].中华结核和呼吸杂志，2017，40（12）：936-938.
[2]	崔力沙，谌望孙，刘卓，等.慢性阻塞性肺疾病的气道黏液高分泌及其靶向治疗[J].医药导报，2017，36（S1）：55-57.
[3]	樊有，顾晓燕，蒋德升，等.噻托溴铵联合N-乙酰半胱氨酸及呼吸训练治疗稳定期中度慢阻肺的临床观察[J].临床肺科杂志，2016，21（3）：498-501.
[4]	张斌.N-乙酰半胱氨酸治疗矽肺合并稳定期慢性阻塞性肺疾病的临床研究[J].中国现代医学杂志，2016，26（5）：128-130.
[5]	金正瑞，韩军侠，张兴文.小剂量阿奇霉素联合信必可都保治疗稳定期慢性阻塞性肺疾病的疗效分析[J].安徽医学，2017，38（5）：591-594.
[6]	郑宏兴，傅科锋，傅婷霞，等.肺康复锻炼对慢性阻塞性肺疾病患者活动耐力和生活质量的影响[J].中国慢性病预防与控制，2017，25（3）：210-213.
[7]	高恒兴，温中梅，袁海波，等.慢性阻塞性肺病发病机制研究的最新进展[J].中国老年学杂志，2015，35（19）：5668-5670.
[8]	谢泉馨.清金化痰汤治疗痰热阻肺型慢性阻塞性肺疾病急性发作的疗效及对气道黏液高分泌性的影响[J].现代中西医结合杂志，2016，25（31）：3480-3482.
[9]	周佳，周向东，许瑞，等.蛋白酶激活受体2在人中性粒细胞弹性蛋白酶诱发气道黏液速发式分泌中的作用及机制[J].华中科技大学学报，2015，44（5）：634-639.
[10]	孙志芬，曲桂红，张媚霞，等.阿奇霉素联合百令胶囊治疗慢性阻塞性肺疾病疗效观察[J].中国药师，2016，19（7）：1311-1313.
[11]	黄招兰，杨贵丽，王惠玲，等.小剂量阿奇霉素治疗对慢性阻塞性肺疾病稳定期老年患者肺功能和炎症因子的影响[J].中国老年学杂志，2016，36（1）：135-136.
[12]	任薇.阿奇霉素对慢性阻塞性肺疾病模型大鼠气道炎症和气道黏液高分泌的影响[D].安徽：安徽医科大学，2016.
[13]	李涛，刘向群，刘景双.小剂量阿奇霉素对稳定期老年慢性阻塞性肺疾病患者外周血内TNF-α、IL-8、CRP水平及肺功能的影响[J].中国药物警戒，2016，13（8）：460-463.
[14]	涂晶，苗润丰，邹晓东，等.N-乙酰半胱氨酸对慢性阻塞性肺疾病合并肺气肿患者血清炎性因子及肺功能的影响分析[J].疑难病杂志，2017，16（12）：1221-1224.
[15]	韩晶，毛锦娟.N-乙酰半胱氨酸对老年慢性阻塞性肺疾病患者肺功能及细胞因子的影响[J].临床肺科杂志，2016，21（6）：1139-1141.