白介素-22和肝纤四项检测对肝纤维化程度的诊断价值

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Abstract Objective To observe the diagnostic values of interleukin-22 (IL-22)and four items detection of liver fibrosis on the liver fibrosis degree.Methods A tatal of 90 cases of patients diagnosed with liver fibrosis by needle biopsy in Tangxia Hospital of Dongguan City from December 2013 to December 2017 were selected as the subjects.The levels of serum IL-22 and four items of liver fibrosis[hyaluronic acid(HA),collagen typeⅣ (C-Ⅳ),procollagenⅢN-terminal peptide(PⅢNP),laminin(LN)]were compared in patients with liver fibrosis at different pathological stages,and the correlation between the above serological indexes and the liver fibrosis degree and its diagnostic values on the liver fibrosis degree were analyzed.Results The serum levels of IL-22,HA,C-Ⅳ,PⅢNP and LN were increased with the severity of liver fibrosis(P＜0.05).Spearman correlation analysis showed that serum levels of IL-22,HA,C-Ⅳ,PⅢNP and LN were significantly and positively correlated with the liver fibrosis degree (r=0.634,0.612,0.563,0.551,0.547,P＜0.05).The diagnostic accuracy of liver fibrosis degree was 84.68%by combined diagnosis of serum IL-22,HA,C- Ⅳ,PⅢNP and LN,which was significantly higher than that by single detection with 77.59% (P＜0.05).Conclusion The levels of serum IL-22 and four items of liver fibrosis are increased with the severity of liver fibrosis,and there is a significant positive correlation with liver fibrosis degree.The combined detection of above indexes can significantly improve the diagnostic accuracy of liver fibrosis degree.

Key words： Four items of liver fibrosis Liver fibrosis degree Correlation Diagnostic values

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	YANG Jie-wen
	HONG Jun-na
	FANG Jia
	XUE Feng
	JIN Wei-xun

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YANG Jie-wen,HONG Jun-na,FANG Jia, et al. Diagnostic values of interleukin-22 and four items detection of liver fibrosis on liver fibrosis degree[J]. 中国当代医药, 2018, 25(27): 123-125转135.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I27/123

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