维生素C联合盐酸雷尼替丁胶囊治疗复发性口腔溃疡的效果

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Abstract Objective To explore the clinical effect of application of combination of Vitamin C and Ranitidine Hydrochlorlde Capsules in the treatment of recurrent oral ulcer(ROU)and its influence on the patients'immune function.Methods Altogether 140 cases with ROU who were treated in our hospital from April 2016 to April 2017 were selected as the subjects of this research,and divided into the control group (70 cases)and the observation group (70 cases)according to the random number method.Patients in the control group were treated with Vitamin C,while the patients in the observation group were treated with the combination of Vitamin C and Ranitidine Hydrochlorlde Capsules.The total effective rate and the changes of various indexes of the two groups,such as T lymphocyte positive (CD3+),auxiliary T lymphocyte positive(CD4+),suppressor/cytotoxic T lymphocyte positive(CD8+)and CD4+/CD8+were compared.Results The total effective rate of the observation group was significantly higher than that of the control group,with statistically significant difference (P＜0.05).The post-treatment CD3+level of the observation group was significantly higher than that of the control group,with statistically significant difference (P＜0.05).There was nostatistically significant difference in CD4+between the observation group and the control group(P＞0.05).The CD8+level of the observation group was significantly lower than that of the control group,with statistically significant difference (P＜0.05).The CD4+/CD8+level of the observation group was significantly higher than that of the control group,with statistically significant difference (P＜0.05).Conclusion Application of combination of Vitamin C and Ranitidine Hydrochlorlde Capsules achieves significant effect in the treatment of ROU,conduciveness to ulcer healing and improvement of patients'immune function,which is worth popularizing in clinical practice.

Key words： Vitamin C Ranitidine Hydrochlorlde Capsules Recurrent oral ulcer

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LI Min. Effect of application of combination of Vitamin C and Ranitidine Hydrochlorlde Capsules in the treatment of recurrent oral ulcer[J]. 中国当代医药, 2018, 25(27): 114-116.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I27/114

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