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| Clinical effect observation of Glimepiride in the treatment of type 2 diabetes patients with secondary failure of traditional Sulfonylureas |
| KE Rui-qiong FANG Xiang-nan WANG Yang QIN Yong-zhang XIAO Li-xia LYU Wei-ming▲ |
| Department of Endocrinology,the First Affiliated Hospital of Gannan Medical College,Jiangxi Province,Ganzhou 341000,China |
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Abstract Objective To observe the clinical effect of application of Glimepiride in the treatment of Type 2 diabetes patients with secondary failure of traditional Sulfonylureas.Methods Altogether 70 type 2 diabetes patients with secondary failure who were treated with traditional Sulfonylureas in our hospital from March 2015 to September 2017 were involved as the subjects of this research,and they were divided into study group(35 cases)and control group(35 cases).After 2-week discontinuation of the original Sulfonylureas,patients in study group were given Glimepiride and the patients in control group were treated with Repaglinide,patients were treated for 24 weeks.Changes in fasting blood glucose,2 h postprandial blood glucose,fasting insulin,glycosylated hemoglobin,body mass index(BMI),insulin resistance,islet function and adverse reactions were observed before and after treatment in the two groups.ResultsThe fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin and insulin resistance of two groups after treatment were lower than those before treatment,while the fasting insulin of two groups was higher than before treatment,with statistically significant differences(P＜0.05).There were no statistically significant difference in islet β-cell function and BMI between the two groups before and after treatment(P＞0.05).The fasting blood glucose,glycated hemoglobin and insulin resistance of study group were lower than those of the control group,with statistically significant differences(P＜0.05).There were no serious adverse reactions in the two groups.Conclusion Application of Glimepiride in the treatment of patients with secondary failure of type 2 diabetes who previously underwent traditional Sulfonylurea treatment,can further improve patients'blood glucose and insulin resistance without increase of adverse reactions.Glimepiride can be used as an effective scheme in the treatment of Type 2 diabetes patients with secondary.
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