CT指导超时间窗脑梗死患者阿替普酶静脉溶栓疗效观察

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Abstract Objective To study the clinical effect of thrombolytic therapy with Alteplase for patients with acute extending thrombolytic time window cerebral infarction guided by CT.Methods From October 2015 to March 2018,56 patients with acute ischemic stroke and reached hospital within 6 hours and received intravenous thrombolysis treated in Department of Emergency of our hospital were selected as the subjects.They were divided into group A and group B by the onset to treatment time.Group A was rt-PA therapy started 0～4.5 h (30 cases),group B was rt-PA therapy started 4.5～6.0 h (26 cases).They all received standard dose intravenous rt-PA thrombolytic therapy,the patient of group B received multimodal CT.The patients of the two group patients have a normal CT scan in 24 h after intravenous thrombolysis.The NIHSS score at different time and the adverse effects were recorded.Results The NIHSS scores after intravenous thrombolysis([3.8±1.8]points)were lower than that before intravenous thrombolysis([11.6±3.2]points)in group A,the difference was statistically significant(P＜0.05).The NIHSS scores after intravenous thrombolysis ([4.5±2.7]points)were lower than that before intravenous thrombolysis([13.1±2.3]points)in group B,the difference was statistically significant(P＜0.05).The NIHSS scores after 7 d treatment in group A was lower than that in group B,the difference was statistically significant(P＜0.05).There was no statistical significance in the adverse effects incidence between the two groups.Conclusion Intravenous thrombolysis with rt-PA in patients with acute extending thrombolytic time window cerebral infarction guided by CT can significantly improve the blood perfusion,promote the recovery of neurological function,and is safety.

Key words： Tissue plasminogen activator Acute cerebral infarction Extending thrombolytic time window

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LIAO Xiang-ming. Efficacy observation of thrombolytic therapy with Alteplase for patients with acute extending thrombolytic time window cerebral infarction guided by CT[J]. 中国当代医药, 2018, 25(27): 65-67.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I27/65

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